POMT2

Last Update:2022-01-07

POMT2 encodes protein O-mannosyltransferase 2. POMT1 and POMT2 transfer Man to the hydroxyl group of Ser or Thr of specific proteins such as alpha-dystroglycan using mannose dolicholate as a sugar donor. POMT1 and POMT2 are multiple transmembrane proteins, respectively, and form a complex in the endoplasmic reticulum to exert enzymatic activities. Both POMT1 and POMT2 genes are known to be causative genes of Walker-Warburg syndrome, a congenital muscular dystrophy.

Keyword:

Mannosyltransferases

GGDB Symbol

POMT2 Alias

Designation

putative protein O-mannosyl-transferase

Organism

Homo sapiens

GeneID

29954

HGNC

POMT2 (19743)

mRNA

NM_013382

map

14q24.3

Protein

NP_037514

EC#

2.4.1.109

CAZy

GT39

GlyCosmos Glycogenes

POMT2

OMIM

607439

Disease name

GDGDB

Human Protein Atlas

ENSG00000009830

Open ALL Close ALL

Orthologous Gene

Mus musculus

mRNA	NM_153415
Protein	NP_700464
MGI	85381

Rattus norvegicus

mRNA	XM_345709
Protein	XP_345709

Caenorhabditis elegans

mRNA	NM_058919
Protein	NP_491320

Drosophila melanogaster

mRNA	NM_130502
Protein	NP_569858

Acceptor Substrates (Reference)

Proc. Natl. Acad. Sci. U.S.A. 2002-11-01 ;12(11):771-83.

Characterization of POMT2, a novel member of the PMT protein O-mannosyltransferase family specifically localized to the acrosome of mammalian spermatids.

Willer T. et al. PMID:12460945

Proc. Natl. Acad. Sci. U.S.A. 2004-01-01 ;101(2):500-5.

Demonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activity.

Manya H. et al. PMID:14699049

DONOR : Dol-P-Man

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

		Dol-P-Man

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Proc. Natl. Acad. Sci. U.S.A. 2002-11-01 ;12(11):771-83.

Characterization of POMT2, a novel member of the PMT protein O-mannosyltransferase family specifically localized to the acrosome of mammalian spermatids.

Willer T. et al. PMID:12460945

braineyeheartkidneyliverlungovarypancreasprostateskeletal musclesmooth musclespleentestisthymusthyroid glanduterus

Gene Ontology

Provided by GOA

Function
dolichyl-phosphate-mannose-protein mannosyltransferase activity
metal ion binding

Process
cell wall mannoprotein biosynthetic process
chain elongation of O-linked mannose residue
multicellular organism development
protein O-linked glycosylation
protein O-linked mannosylation
regulation of endoplasmic reticulum unfolded protein response

Component
dolichyl-phosphate-mannose-protein mannosyltransferase complex
endoplasmic reticulum membrane
integral component of membrane

This page does not indicate all of the enzymatic reaction, and expression of "POMT2".