DPM1

Last Update:2016-08-10

DPM1 encodes the catalytic subunit of dolichyl-phosphate mannosyltransferase. Dolichol-phosphate-mannose is required for the synthesis of lipid-linked oligosaccharides and glycosylphosphatidylinositol anchor in the endoplasmic reticulum. Dolichyl-phosphate mannosyltransferase consists of three subunits, DPM1, DPM2 and DPM3. GDP-mannose and dolichol-phosphate are used as donor and acceptor substrates, respectively. Mutation of DPM1 is associated with congenital disorder of glycosylation type 1E.

Keyword: congenital disorders of glycosylation ,  dolichol-phosphate-mannose
dolichol-phosphate dolichol-phosphate-mannose

Mannosyltransferases


GGDB Symbol DPM1    Alias
Designationdolichol-phosphate mannosyltransferase polypeptide 1, catalytic subunit
OrganismHomo sapiens
GeneID 8813
HGNC DPM1 (3005)
mRNA NM_003859
map20q13.13
Protein NP_003850
EC# 2.4.1.83   
CAZy GT2   
GlyCosmos Glycogenes DPM1
OMIM 603503
Disease name CDG Ie ,  Congenital Disorder of Glycosylation type Ie
GDGDB CON00347   
Human Protein Atlas ENSG00000000419
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Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "DPM1".