ALG1

Last Update:2016-08-10

ALG1 encodes beta-1,4-mannosyltransferase that is involved in the synthesis of lipid-linked oligosaccharides in the endoplasmic reticulum. GDP-mannose and chitobiosyldiphosphodolichol are used as donor and acceptor substrates, respectively. ALG1 complements the defect of the yeast alg1 mutant. Mutation of ALG1 is associated with congenital disorder of glycosylation type 1K.

Keyword: congenital disorders of glycosylation ,  lipid-linked oligosaccharide
JCGG-STR008492
GlyTouCan: G05026ZL
GlyCosmos Glycans: G05026ZL
JCGG-STR024580
GlyTouCan: G65996GC
GlyCosmos Glycans: G65996GC

Mannosyltransferases


GGDB Symbol ALG1    Alias
DesignationGDP-Mannose:GlcNAc2-PP-dolichol beta-1,4-mannosyltransferase
OrganismHomo sapiens
GeneID 56052
HGNC ALG1 (18294)
mRNA NM_019109
map16p13.3
Protein NP_061982
EC# 2.4.1.142   
CAZy
GlyCosmos Glycogenes ALG1
OMIM 605907
Disease name CDG Ik ,  Congenital Disorder of Glycosylation type Ik
GDGDB CON00353   
Human Protein Atlas ENSG00000033011
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Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "ALG1".