The 3GnT3 (B3GNT3) enzyme transfers GlcNAc to the core 1 O-glycan (Galβ1-3GalNAc-O-Ser/Thr) structure and elongates it to form the elongated core 1 O-glycan (GlcNAcβ1-3Galβ1-3GalNAc-O-Ser/Thr) structure. The 6-sulfated sialyl Lewis X antigen, including the MECA-79 antibody epitope, exists on the elongated core 1 O-glycan. As it has been reported that it is involved as the high endothelial venules (HEV)-L-selectin ligand, which is necessary for the homing of leukocytes.
Keyword:
elongated core 1 O-glycan
, poly-N-acetyllactosamine
, polylactosamine
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JCGG-STR025711
GlyTouCan:
G00031MO
GlyCosmos Glycans:
G00031MO
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JCGG-STR026235
GlyTouCan:
G75472OU
GlyCosmos Glycans:
G75472OU
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N-Acetylglucosaminyltransferase
| B3GNT3 Alias | |
| Designation | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3 |
| Organism | Homo sapiens |
| GeneID | 10331 |
| HGNC | B3GNT3 (13528) |
| mRNA | NM_014256 |
| map | 19p13.1 |
| Protein | NP_055071 |
| EC# | 2.4.1.146 |
| CAZy | GT31 |
| GlyCosmos Glycogenes | B3GNT3 |
| OMIM | 605863 |
| GDGDB | |
| Human Protein Atlas | ENSG00000179913 |
Mus musculus
Rattus norvegicus
Arabidopsis thaliana
