DPM3 encodes a subunit of dolichyl-phosphate mannosyltransferase. Dolichol-phosphate-mannose is required for the synthesis of lipid-linked oligosaccharides and glycosylphosphatidylinositol anchor in the endoplasmic reticulum. Dolichyl-phosphate mannosyltransferase consists of three subunits, DPM1, DPM2 and DPM3. GDP-mannose and dolichol-phosphate are used as donor and acceptor substrates, respectively. DPM3 stabilizes the dolichyl-phosphate mannosyltransferase complex. Mutation of DPM3 is associated with congenital disorder of glycosylation type 1O.
Keyword:
congenital disorders of glycosylation
, dolichol-phosphate-mannose
| dolichol-phosphate | 
|
dolichol-phosphate-mannose |
Mannosyltransferases
| DPM3 Alias | |
| Designation | dolichol-phosphate mannosyltransferase polypeptide 3 |
| Organism | Homo sapiens |
| GeneID | 54344 |
| HGNC | DPM3 (3007) |
| mRNA | NM_018973 |
| map | 1q22 |
| Protein | NP_061846 |
| EC# | 2.4.1.83 |
| CAZy | GT2 |
| GlyCosmos Glycogenes | DPM3 |
| OMIM | 605951 |
| GDGDB | |
| Human Protein Atlas | ENSG00000179085 |
Mus musculus