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JCGG-STR009323 JCGG-STR006994
JCGG-STR009224 JCGG-STR006972
β1,4-N-Acetylglucosaminyltransferase-IV (MGAT4) transfers GlcNAc toβ1-4 of mannose on the GlcNAcβ1-2Manα1-3 structure (GlcNAcβ1-2Manα1-3Manβ1-R) synthesized by MGAT1. MGAT4 does not have activity or affinity to the glycan structure synthesized by MGAT3 by receiving bisect GlcNac. MGAT4A, which has high homology to bovine enzymes, and MGAT4B, which has low homology to bovine enzymes, are known as MGAT4. Both are characterized as similar optimal pH and Mn2+ concentration, but are different in cation dependency. Co2+ can activate MGAT4B comparably to that Mn2+ does.
GNT-IV GNT-IVA

N-Acetylglucosaminyltransferase

GGDB SymbolMGAT4A
Alias GNT-IV, GNT-IVA    details
Designationmannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A
OrganismHomo sapiens
GeneID 11320
HGNC 7047
mRNA NM_012214       (CDS)
Protein NP_036346       (CDS)
map2q12
EC# 2.4.1.145   
CAZy GT54   
OMIM 604623   
This page does not indicate all of the enzymatic reaction, and expression of "MGAT4A".