GGDB:

This gene encodes α1,3-fucosyltransferase 6 (FUT6). Six α1,3-fucosyltransferases (α3FUT): FUT3, FUT4, FUT5, FUT6, FUT7, and FUT9 are known and confirmed that each enzyme has a characteristic substrate specificity in vitro. FUT6 has activity to transfer fucose to GlcNAc of type-2 lactosamine structure (Galβ1-4GlcNAcβ1-3-R) or sialylated type-2 lactosamine structure (NeuAcα2-3Galβ1-4GlcNAcβ1-3-R) with α1-3-linkage, and related to synthesis of Lewis x (Lex) or sialyl Lewis x (sLex) antigens. FUT6 is known to be related to many type-2 Lewis blood group antigens (i.e. Lea, Lex, Ley, sLea, sLex, and others).

Keyword: Lewis blood group , Lewis x , Lewis y , histoblood group antigen , sialyl Lewis x

	GDP-Fuc
JCGG-STR027036 GlyTouCan: G46055MA GlyCosmos Glycans: G46055MA		JCGG-STR033543 GlyTouCan: G95693MA GlyCosmos Glycans: G95693MA

Fucosyltransferase

GGDB Symbol

FUT6 Alias

Designation

alpha1,3-fucosyltransferase 6

Organism

Homo sapiens

GeneID

2528

HGNC

FUT6 (4017)

mRNA

NM_000150

map

19p13.3

Protein

NP_000141

EC#

2.4.1.152

CAZy

GT10

GlyCosmos Glycogenes

FUT6

OMIM

136836

Disease name

GDGDB

Human Protein Atlas

ENSG00000156413

Drosophila melanogaster

mRNA	AY071324
Protein	AAL48946

FEBS Lett. 1999-12-01 ;462(3):289-94.

Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue.

Nishihara S. et al. PMID:10622713 Refer to: Figure 3,Figure 4

DONOR : GDP-Fuc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR027036 GlyTouCan: G46055MA GlyCosmos Glycans: G46055MA	GDP-Fuc	JCGG-STR033543 GlyTouCan: G95693MA GlyCosmos Glycans: G95693MA

J. Biol. Chem. 2001-10-01 ;11(10):119R-128R.

Fucosyltransferases: structure/function studies.

de Vries T. et al. PMID:11588153

FEBS Lett. 1995-08-01 ;270(34):20112-22.

Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.

Cameron HS. et al. PMID:7650030

J. Biol. Chem. 1997-03-01 ;272(13):8764-73.

Molecular cloning and expression of a bovine alpha(1,3)-fucosyltransferase gene homologous to a putative ancestor gene of the human FUT3-FUT5-FUT6 cluster.

Oulmouden A. et al. PMID:9079712 Refer to: Table III.

DONOR : GDP-Fuc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR002937 GlyTouCan: G61459JW GlyCosmos Glycans: G61459JW	GDP-Fuc	JCGG-STR022315 GlyTouCan: G00052MO GlyCosmos Glycans: G00052MO

	JCGG-STR031527 GlyTouCan: G00065MO GlyCosmos Glycans: G00065MO	GDP-Fuc	JCGG-STR003144 GlyTouCan: G00054MO GlyCosmos Glycans: G00054MO

	JCGG-STR012567 GlyTouCan: G03499BP GlyCosmos Glycans: G03499BP	GDP-Fuc	JCGG-STR007029 GlyTouCan: G08176ZW GlyCosmos Glycans: G08176ZW

Substrate Not Transferred

	JCGG-STR021875 GlyTouCan: G40696TO GlyCosmos Glycans: G40696TO

J. Biol. Chem. 1997-10-01 ;7(7):921-7.

Acceptor specificity of GDP-Fuc:Gal beta 1-->4GlcNAc-R alpha 3-fucosyltransferase VI (FucT VI) expressed in insect cells as soluble, secreted enzyme.

De Vries T. et al. PMID:9363434

J. Biol. Chem. 1998-11-01 ;273(47):30985-94.

In vivo specificity of human alpha1,3/4-fucosyltransferases III-VII in the biosynthesis of LewisX and Sialyl LewisX motifs on complex-type N-glycans. Coexpression studies from bhk-21 cells together with human beta-trace protein.

Grabenhorst E. et al. PMID:9812995

DONOR : GDP-Fuc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

		GDP-Fuc
	JCGG-STR025848 GlyTouCan: G64973KT GlyCosmos Glycans: G64973KT		JCGG-STR027221 GlyTouCan: G17752YB GlyCosmos Glycans: G17752YB

		GDP-Fuc
	JCGG-STR027483 GlyTouCan: G11457RF GlyCosmos Glycans: G11457RF		JCGG-STR008757 GlyTouCan: G41245OZ GlyCosmos Glycans: G41245OZ

		GDP-Fuc
	JCGG-STR031449 GlyTouCan: G97494HI GlyCosmos Glycans: G97494HI		JCGG-STR031450 GlyTouCan: G94541HG GlyCosmos Glycans: G94541HG

		GDP-Fuc
	JCGG-STR027300 GlyTouCan: G32723SL GlyCosmos Glycans: G32723SL		JCGG-STR031465 GlyTouCan: G02522JF GlyCosmos Glycans: G02522JF

		GDP-Fuc
	JCGG-STR031464 GlyTouCan: G64844ET GlyCosmos Glycans: G64844ET		JCGG-STR004795 GlyTouCan: G88696BY GlyCosmos Glycans: G88696BY

		GDP-Fuc
	JCGG-STR004435 GlyTouCan: G23438NR GlyCosmos Glycans: G23438NR		JCGG-STR031467 GlyTouCan: G47557KS GlyCosmos Glycans: G47557KS

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

FEBS Lett. 1995-08-01 ;270(34):20112-22.

Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.

Cameron HS. et al. PMID:7650030

bladdercolonkidneyliversalivary glandsmall intestineuterus

Provided by GOA

Function
3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
alpha-(1->3)-fucosyltransferase activity
fucosyltransferase activity

Process
L-fucose catabolic process
fucosylation
protein N-linked glycosylation
protein glycosylation

Component
Golgi apparatus
Golgi cisterna membrane
Golgi membrane
extracellular exosome
integral component of membrane

FUT6

Fucosyltransferase

Orthologous Gene

Drosophila melanogaster

Acceptor Substrates (Reference)

Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue.

DONOR : GDP-Fuc

Substrate Transferred

Fucosyltransferases: structure/function studies.

Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.

Molecular cloning and expression of a bovine alpha(1,3)-fucosyltransferase gene homologous to a putative ancestor gene of the human FUT3-FUT5-FUT6 cluster.

DONOR : GDP-Fuc

Substrate Transferred

Substrate Not Transferred

Acceptor specificity of GDP-Fuc:Gal beta 1-->4GlcNAc-R alpha 3-fucosyltransferase VI (FucT VI) expressed in insect cells as soluble, secreted enzyme.

In vivo specificity of human alpha1,3/4-fucosyltransferases III-VII in the biosynthesis of LewisX and Sialyl LewisX motifs on complex-type N-glycans. Coexpression studies from bhk-21 cells together with human beta-trace protein.

Acceptor Substrates (KEM-C)

DONOR : GDP-Fuc

Substrate Transferred

Expression

Expression (Reference)

Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms.

Gene Ontology