GGDB:

FUT8	Last Update:2021-12-17

FUT8がコードするα1-6フコース転移酵素は、ドナー基質であるGDP-Fucから、アクセプター基質である複合型N結合型糖鎖の根元のGlcNAcに、α1-6結合でFucを転移し、コアフコース構造を合成する。コアフコース構造は、様々な糖タンパク質のN結合型糖鎖に一般的に見られる構造であるが、α-フェトプロテインの糖鎖上のコアフコースの増加は、肝細胞がんの有用な血清マーカーとして知られている。

Keyword: コアフコース

Fucosyltransferase

GGDB Symbol

FUT8 Alias

Designation

alpha1,6-fucosyltransferase 8

Organism

Homo sapiens

GeneID

2530

HGNC

FUT8 (4019)

mRNA

NM_178154

map

14q24.3

Protein

NP_835367

EC#

2.4.1.68

CAZy

GT23

GlyCosmos Glycogenes

FUT8

OMIM

602589

Disease name

GDGDB

Human Protein Atlas

ENSG00000033170

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Orthologous Gene

Mus musculus

mRNA	NM_016893
Protein	NP_058589
KO_mice_database	33
MGI	46581

Rattus norvegicus

mRNA	NM_001002289
Protein	NP_001002289

Caenorhabditis elegans

mRNA	NM_072154
Protein	NP_504555

Drosophila melanogaster

mRNA	NM_132512
Protein	NP_572740

Acceptor Substrates (Reference)

J. Biol. Chem. 1991-11-01 ;266(32):21572-7.

Purification and characterization of GDP-L-fucose-N-acetyl beta-D-glucosaminide alpha 1----6fucosyltransferase from cultured human skin fibroblasts. Requirement of a specific biantennary oligosaccharide as substrate.

Voynow JA. et al. PMID:1939186

DONOR : GDP-Fuc

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR009224 GlyTouCan: G39213VZ GlyCosmos Glycans: G39213VZ	GDP-Fuc	JCGG-STR017422 GlyTouCan: G80858MF GlyCosmos Glycans: G80858MF

Expression

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

J. Biol. Chem. 2004-01-01 ;14(1):13-25.

Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis.

Martinez-Duncker I. et al. PMID:14514715

braincolonfetal brainfetal heartfetal kidneyfetal liverfetal lungfetal skeletal musclefetal skinfetal small intestineheartileumjejunumkidneylungpancreasplacentarectumskeletal musclespleenstomachurinary bladderuterus

Gene Ontology

Provided by GOA

Function
SH3 domain binding
glycoprotein 6-alpha-L-fucosyltransferase activity

Process
GDP-L-fucose metabolic process
L-fucose catabolic process
N-glycan fucosylation
N-glycan processing
cell migration
in utero embryonic development
integrin-mediated signaling pathway
oligosaccharide biosynthetic process
protein N-linked glycosylation
protein N-linked glycosylation via asparagine
protein glycosylation in Golgi
receptor metabolic process
regulation of cellular response to oxidative stress
regulation of gene expression
respiratory gaseous exchange
transforming growth factor beta receptor signaling pathway

Component
Golgi apparatus
Golgi cisterna membrane
Golgi membrane
cytoplasm
extracellular exosome
integral component of membrane
membrane

This page does not indicate all of the enzymatic reaction, and expression of "FUT8".