FUT11

This gene encodes α1,3-fucosyltransferase 11 (FUT11). In in vitro enzyme activity assay, FUT11 enzyme is reported to transfer α1-3 fucose to GlcNAc on a core structure of N-glycans (Man-GlcNAc-GlcNAc-Asn) and synthesize a core α1-3-fucose structure (Mainly transfers to agalacto N-glycans. The activity is relatively weak to biantennary N-glycans). However, although carrier glycoproteins of N-glycans with the core α1-3-fucose structure are reported in plants and insects, these are not reported in human. The enzyme does not show activity to short lactosamine acceptor substrates (i.e. Lewis x antigen synthetic activity), which are generally used in activity assays.