GGDB:

POFUT2 encodes protein O-fucosyltransferase 2. Although two types of O-Fuc modifications are known in vivo, POFUT2 transfer Fuc directly toward Ser or Thr in Thrombospondin type 1 repeat (TSRs) domains. POFUT2, like POFUT1, localizes to the ER. Glc is further attached to the O-Fuc of the TSR domain, but the function of these glycans in vivo is not known.

Keyword: O-fucose , TSR

Fucosyltransferase

GGDB Symbol

POFUT2 Alias

Designation

protein o-fucosyltransferase 2

Organism

Homo sapiens

GeneID

23275

HGNC

POFUT2 (14683)

mRNA

NM_133635

map

21q22.3

Protein

NP_598368

EC#

CAZy

GlyCosmos Glycogenes

POFUT2

OMIM

610249

Disease name

GDGDB

Human Protein Atlas

ENSG00000186866

Mus musculus

mRNA	NM_030262
Protein	NP_084538
MGI	53593

Rattus norvegicus

mRNA	XM_228073
Protein	XP_228073

Caenorhabditis elegans

mRNA	NM_171228
Protein	NP_741272

Drosophila melanogaster

mRNA	NM_130560
Protein	NP_569916

J Biol Chem 2004-08-01 ;84(2):320-30.

The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development.

Menzel O. et al. PMID:15233996

Genomics 2006-04-01 ;281(14):9393-9.

Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats.

Luo Y. et al. PMID:16464857

Genomics 2006-04-01 ;281(14):9385-92.

Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats.

Luo Y. et al. PMID:16464858

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J Biol Chem 2004-08-01 ;84(2):320-30.

The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development.

Menzel O. et al. PMID:15233996

braincolonheartkidneyliver

Provided by GOA

Function
peptide-O-fucosyltransferase activity

Process
fucose metabolic process
mesoderm formation
protein O-linked fucosylation
regulation of epithelial to mesenchymal transition
regulation of gene expression
regulation of secretion

Component
Golgi apparatus
endoplasmic reticulum membrane

POFUT2

Fucosyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Acceptor Substrates (Reference)

The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development.

Protein O-fucosyltransferase 2 adds O-fucose to thrombospondin type 1 repeats.

Two distinct pathways for O-fucosylation of epidermal growth factor-like or thrombospondin type 1 repeats.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development.

Gene Ontology