Last Update:2022-01-07

NDST1 encodes heparan sulfate/heparin GlcNAc N-deacetylase/N-sulfotransferase 1. This enzyme has dual enzymatic activities: N-deacetylase activity and N-sulfotransferase activity. There are four isoenzymes of NDST in humans. NDST deacetylates the N-acetyl group of GlcNAc and transfers the sulfate group using PAPS as the sulfate donor. This reaction is the first step in the sulfation of heparan sulfate, followed by epimerization of GlcA and sulfation of the C2 position of GlcA and the C6- and C3-positions of GlcNAc. The NDST1 and NDST2 genes show ubiquitous expression patterns, while NDST3 and NDST4 genes show tissue-specific expression patterns. NDST3 and NDST4 show tissue-specific gene expression.

Keyword: heparan sulfate ,  heparin


GGDB Symbol NDST1    Alias
DesignationN-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
OrganismHomo sapiens
GeneID 3340
HGNC NDST1 (7680)
mRNA NM_001543
Protein NP_001534
GlyCosmos Glycogenes NDST1
OMIM 600853
Disease name
Human Protein Atlas ENSG00000070614
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Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)


RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "NDST1".