GGDB:

HS2ST1はheparan sulfate 2-O-sulfotransferase 1をコードする。へパラン硫酸のバックボーンはGlcA/IdoAとGlcNAc/GlcNSO3の2糖ユニットの繰り返しで構成され、それぞれの糖に硫酸修飾が起こる。HS2ST1はGlcA/IdoAの2位の硫酸化を触媒する。HS2ST1のノックアウトマウスは胎生致死である。

Keyword: プロテオグリカン , ヘパラン硫酸 , ヘパリン , 硫酸転移酵素

Sulfotransferases

GGDB Symbol

HS2ST1 Alias

Designation

heparan sulfate 2-O-sulfotransferase

Organism

Homo sapiens

GeneID

9653

HGNC

HS2ST1 (5193)

mRNA

NM_012262

map

1p31.1-p22.1

Protein

NP_036394

EC#

2.8.2.8

CAZy

GlyCosmos Glycogenes

HS2ST1

OMIM

604844

Disease name

GDGDB

Human Protein Atlas

ENSG00000153936

Mus musculus

mRNA	NM_011828
Protein	NP_035958
MGI	42703

Rattus norvegicus

mRNA	XM_214740
Protein	XP_214740

Caenorhabditis elegans

mRNA	NM_077470
Protein	NP_509871

Drosophila melanogaster

mRNA	NM_057991
Protein	NP_477339

DNA Res. 1999-04-01 ;274(15):10474-80.

Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate.

Kobayashi M. et al. PMID:10187838

table 1
Glycoprotein	Enzyme activity
CDSNS-heparin (completely desulfated N-resulfated heparin)	11600
Dermatan sulfate	70
Chondroitin	65
Chondroitin sulfate C (Seikagaku; 90% 6-sulfate, 10% 4-sulfate)	50
Dermatan (chemically desulfated dermatan sulfate with small amount of residual 4-sulfate)	45

Biochem. J. 2000-03-01 ;346 Pt 2():463-8.

Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphation.

Rong J. et al. PMID:10677367

J. Biol. Chem. 1997-10-01 ;4(5):345-9.

Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

Seki N. et al. PMID:9455484

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 1997-10-01 ;4(5):345-9.

Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

Seki N. et al. PMID:9455484

brain

Provided by GOA

Function
heparan sulfate 2-O-sulfotransferase activity

Process
glycosaminoglycan biosynthetic process

Component
Golgi membrane
integral component of membrane
membrane

HS2ST1

Sulfotransferases

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Acceptor Substrates (Reference)

Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate.

Expression of heparan sulphate L-iduronyl 2-O-sulphotransferase in human kidney 293 cells results in increased D-glucuronyl 2-O-sulphation.

Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Characterization of cDNA clones in size-fractionated cDNA libraries from human brain.

Gene Ontology