Last Update:2021-12-10

CHST3 encodes carbohydrate (chonsroitin 6) sulfotransferase 3. This enzyme is involved in the biosynthesis of chondroitin sulfate, which is a repeating disaccharide structure of (GalNAcβ1,4GlcAβ1,3)n with highly sulfations. CHST3 has a C6ST activity that transfers sulfate to the 6-position of GalNAc. CHST3 also has activity to transfer sulfate to the linkage tetrasaccharide and to the 6-position of Gal in the keratan sulfate. In humans, there are two isoenzymes, CHST3 and CHST7. Genome-wide association studies (GWAS) have reported that a SNP in the 3' untranslated region of CHST3 is involved in the pathogenesis of lumbar disc degeneration (LDD).

Keyword: chondroitin sulfate ,  keratan sulfate


GGDB Symbol CHST3    Alias
Designationchondroitin 6-sulfotransferase
OrganismHomo sapiens
GeneID 9469
HGNC CHST3 (1971)
mRNA NM_004273
Protein NP_004264
GlyCosmos Glycogenes CHST3
OMIM 603799
Disease name
Human Protein Atlas ENSG00000122863
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Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)


RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "CHST3".