CHST3

CHST3 encodes carbohydrate (chonsroitin 6) sulfotransferase 3. This enzyme is involved in the biosynthesis of chondroitin sulfate, which is a repeating disaccharide structure of (GalNAcβ1,4GlcAβ1,3)n with highly sulfations. CHST3 has a C6ST activity that transfers sulfate to the 6-position of GalNAc. CHST3 also has activity to transfer sulfate to the linkage tetrasaccharide and to the 6-position of Gal in the keratan sulfate. In humans, there are two isoenzymes, CHST3 and CHST7. Genome-wide association studies (GWAS) have reported that a SNP in the 3' untranslated region of CHST3 is involved in the pathogenesis of lumbar disc degeneration (LDD).