CHST5 encodes carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 5. This enzyme is involved in the biosynthesis of keratan sulfate, a type of GAG. Keratan sulfate is a repeating disaccharide structure of (Galβ1,4GlcNAcβ1,3)n, and sulfate is added at position 6 of both Gal and GlcNAc. CHST5 is an enzyme that transfers sulfate to position 6 of GlcNAc in keratan sulfate. Two highly homologous isoenzymes (CHST5 and CHST6) exist in humans, but they are expressed in different tissues. CHST5 is highly expressed in the colon and small intestine.
Keyword:
keratan sulfate
, sulfotransferase
Sulfotransferases
| CHST5 Alias | |
| Designation | intestinal N-acetylglucosamine 6-O-sulfotransferase |
| Organism | Homo sapiens |
| GeneID | 23563 |
| HGNC | CHST5 (1973) |
| mRNA | NM_012126 |
| map | 16q22.3 |
| Protein | NP_036258 |
| EC# | 2.8.2.21 |
| CAZy | |
| GlyCosmos Glycogenes | CHST5 |
| OMIM | 604817 |
| GDGDB | |
| Human Protein Atlas | ENSG00000135702 |
