CHST6 encodes carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 6. This enzyme is involved in the biosynthesis of keratan sulfate, a type of GAG. Keratan sulfate is a repeating disaccharide structure of (Galβ1,4GlcNAcβ1,3)n, and sulfate is added at position 6 of both Gal and GlcNAc. CHST6 is an enzyme that transfers sulfate to position 6 of GlcNAc in keratan sulfate. Two highly homologous isoenzymes （CHST5 and CHST6） exist in humans, but they are expressed in different tissues. CHST6 is highly expressed in the cornea.
Keyword:
keratan sulfate
, sulfotransferase
Sulfotransferases
| CHST6 Alias | |
| Designation | corneal N-acetylglucosamine 6-sulfotransferase |
| Organism | Homo sapiens |
| GeneID | 4166 |
| HGNC | CHST6 (6938) |
| mRNA | NM_021615 |
| map | 16q22 |
| Protein | NP_067628 |
| EC# | 2.8.2.21 |
| CAZy | |
| GlyCosmos Glycogenes | CHST6 |
| OMIM | 605294 |
| GDGDB | |
| Human Protein Atlas | ENSG00000183196 |
Mus musculus
Rattus norvegicus