GGDB:

HS6ST1 encodes heparan sulfate-glucosamine 6-sulfotransferase 1. Heparan sulfate is composed from disaccharide units of HexA and GlcNAc/GlcNSO3 with sulfation. HS6ST catalyzes the sulfation of N-sulfated GlcNAc at C6 position. HS6ST has three types of isoenzymes in humans, and their expression tissues and substrate specificities are different. HS6ST1 is a ubiquitously expressed enzyme and is the causative gene for idiopathic hypogonadotropic hypogonadism.

Keyword: heparan sulfate , heparin , proteoglycan , sulfotransferase

Sulfotransferases

GGDB Symbol

HS6ST1 Alias

Designation

heparan sulfate 6-O-sulfotransferase

Organism

Homo sapiens

GeneID

9394

HGNC

HS6ST1 (5201)

mRNA

NM_004807

map

2q21

Protein

NP_004798

EC#

CAZy

GlyCosmos Glycogenes

HS6ST1

OMIM

604846

Disease name

GDGDB

Human Protein Atlas

ENSG00000136720

Mus musculus

mRNA	NM_015818
Protein	NP_056633
KO_mice_database	137
MGI	46064

Rattus norvegicus

mRNA	XM_237060
Protein	XP_237060

Caenorhabditis elegans

mRNA	NM_076494
Protein	NP_508895

Drosophila melanogaster

mRNA	NM_079685
Protein	NP_524409

Biochem. J. 2003-04-01 ;371(Pt 1):131-42.

Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.

Habuchi H. et al. PMID:12492399

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Biochem. J. 2003-04-01 ;371(Pt 1):131-42.

Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.

Habuchi H. et al. PMID:12492399

adrenal glandsbraincolonfetal brainfetal heartfetal kidneyfetal liverfetal lungfetal spleenfetal thymusheartkidneyliverlungovarypancreasplacentaprostateskeletal musclesmall intestinespleenstomachtestisthymusuterus

Provided by GOA

Function
heparan sulfate 6-O-sulfotransferase activity
sulfotransferase activity

Process
angiogenesis
glycosaminoglycan biosynthetic process
heparan sulfate proteoglycan biosynthetic process, enzymatic modification
labyrinthine layer blood vessel development
lung alveolus development
neuron development

Component
Golgi membrane
integral component of plasma membrane

HS6ST1

Sulfotransferases

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Acceptor Substrates (Reference)

Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.

Gene Ontology