GGDB:

HS6ST2 encodes heparan sulfate-glucosamine 6-sulfotransferase 2. Heparan sulfate is composed from disaccharide units of HexA and GlcNAc/GlcNSO3 with sulfation. HS6ST catalyzes the sulfation of N-sulfated GlcNAc at C6 position. HS6ST has three types of isoenzymes in humans, and their expression tissues and substrate specificities are different. Although there are two isoforms of HS6ST2 with different lengths (HS6ST-2, HS6ST-2S), their substrate specificities are different. The full-length isoform HS6ST-2 transfers sulfate to GlcNSO3 in the Ido(2SO4)-GlcNSO3 unit, whereas HS6ST-2S transfers sulfate to GlcNSO3 in the GlcA-GlcNSO3 unit in addition to the Ido(2SO4)-GlcNSO3 unit.

Keyword: heparan sulfate , heparin , proteoglycan , sulfotransferase

Sulfotransferases

GGDB Symbol

HS6ST2 Alias

Designation

heparan sulfate 6-O-sulfotransferase 2

Organism

Homo sapiens

GeneID

90161

HGNC

HS6ST2 (19133)

mRNA

NM_147174

map

Xq26.2

Protein

NP_671703

EC#

CAZy

GlyCosmos Glycogenes

HS6ST2

OMIM

300545

Disease name

GDGDB

Human Protein Atlas

ENSG00000171004

Mus musculus

mRNA	NM_015819
Protein	NP_056634
KO_mice_database	138
MGI	46065

Rattus norvegicus

mRNA	XM_228683
Protein	XP_228683

J Biol Chem 2000-01-01 ;275(4):2859-68.

The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine.

Habuchi H. et al. PMID:10644753

J Biol Chem 2003-04-01 ;371(Pt 1):131-42.

Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.

Habuchi H. et al. PMID:12492399

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J Biol Chem 2000-01-01 ;275(4):2859-68.

The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine.

Habuchi H. et al. PMID:10644753

brainfetal brainfetal kidneykidneyovarypancreaspituitary glandplacentatestistrachea

Provided by GOA

Function
heparan sulfate 6-O-sulfotransferase activity

Process
glycosaminoglycan biosynthetic process
heparan sulfate proteoglycan biosynthetic process, enzymatic modification

Component
Golgi membrane
extracellular exosome
integral component of membrane
nucleoplasm

HS6ST2

Sulfotransferases

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine.

Biosynthesis of heparan sulphate with diverse structures and functions: two alternatively spliced forms of human heparan sulphate 6-O-sulphotransferase-2 having different expression patterns and properties.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine.

Gene Ontology