CHST10

Last Update:2017-03-27

本遺伝子がコードする酵素は、HNK-1糖鎖抗原(HSO3-GlcAb1-3Galb1-4GlcNAc-R)の合成に関与する酵素群の一つであり、その酵素活性としては、供与体基質であるPAPS(3'-phosphoadenosine-5'-phosphosulfate)から硫酸基を、受容体基質（GlcAb1-3Galb1-4GlcNAc-R）の非還元末端に存在するグルクロン酸(GlcA)残基へ転移するものである。

Keyword: HNK-1抗原 (ヒトナチュラルキラー1抗原)

	PAPS
JCGG-STR007574 GlyTouCan: G10271ZL GlyCosmos Glycans: G10271ZL		JCGG-STR033296

Sulfotransferases

GGDB Symbol

CHST10 Alias

Designation

HNK-1 sulfotransferase

Organism

Homo sapiens

GeneID

HGNC

CHST10 (19650)

mRNA

map

2q11.2

Protein

EC#

CAZy

GlyCosmos Glycogenes

CHST10

OMIM

606376

Disease name

GDGDB

Human Protein Atlas

ENSG00000115526

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Orthologous Gene

Mus musculus

mRNA	NM_145142
Protein	NP_660124
MGI	65723

Rattus norvegicus

mRNA	NM_080397
Protein	NP_536322

Acceptor Substrates (Reference)

J. Biol. Chem. 2000-06-01 ;275(26):20188-96.

Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family.

Hiraoka N. et al. PMID:10781601

table 1
Glycoprotein	Enzyme activity
Dermatan sulfate (chondroitin sulfate B)	0
Chondroitin sulfate	0
Completely desulfated and N-sulfated heparin (CDSNS)	0
Chondroitin	0
Completely desulfated and N-acetylated heparin (CDSNAc)	0
Keratan sulfate	0
Chondroitin sulfate C	0

J. Biol. Chem. 2001-04-01 ;276(14):10861-9.

Molecular cloning and expression of an N-acetylgalactosamine-4-O-sulfotransferase that transfers sulfate to terminal and non-terminal beta 1,4-linked N-acetylgalactosamine.

Kang HG. et al. PMID:11139592 Refer to: Table II

DONOR : PAPS

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR003511 GlyTouCan: G99041PQ GlyCosmos Glycans: G99041PQ	PAPS	JCGG-STR032578

Substrate Not Transferred

	JCGG-STR018696 GlyTouCan: G43702JT GlyCosmos Glycans: G43702JT

	JCGG-STR018783 GlyTouCan: G59461YM GlyCosmos Glycans: G59461YM

	JCGG-STR029533 GlyTouCan: G00057MO GlyCosmos Glycans: G00057MO

J. Biol. Chem. 1997-11-01 ;272(47):29942-6.

Expression cloning of a cDNA encoding a sulfotransferase involved in the biosynthesis of the HNK-1 carbohydrate epitope.

Bakker H. et al. PMID:9368071 Refer to: Fig. 3

DONOR : PAPS

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR007574 GlyTouCan: G10271ZL GlyCosmos Glycans: G10271ZL	PAPS	JCGG-STR033296

J. Biol. Chem. 1998-02-01 ;273(9):5190-5.

Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids.

Ong E. et al. PMID:9478973 Refer to: FIG. 6. Fig. 7

DONOR : PAPS

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR007574 GlyTouCan: G10271ZL GlyCosmos Glycans: G10271ZL	PAPS	JCGG-STR030505 GlyTouCan: G17576WI GlyCosmos Glycans: G17576WI

	JCGG-STR025412 GlyTouCan: G87867IZ GlyCosmos Glycans: G87867IZ	PAPS	JCGG-STR002718 GlyTouCan: G39133HC GlyCosmos Glycans: G39133HC

Substrate Not Transferred

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

J. Biol. Chem. 1997-11-01 ;272(47):29942-6.

Expression cloning of a cDNA encoding a sulfotransferase involved in the biosynthesis of the HNK-1 carbohydrate epitope.

Bakker H. et al. PMID:9368071

J. Biol. Chem. 1998-02-01 ;273(9):5190-5.

Expression cloning of a human sulfotransferase that directs the synthesis of the HNK-1 glycan on the neural cell adhesion molecule and glycolipids.

Ong E. et al. PMID:9478973

brainfetal brainfetal kidneyfetal lungheartovarypancreasprostateskeletal musclespleentestisthymus

Gene Ontology

Provided by GOA

Function
HNK-1 sulfotransferase activity
sulfotransferase activity

Process
carbohydrate biosynthetic process
cell adhesion

Component
Golgi apparatus
Golgi membrane
integral component of membrane
membrane

This page does not indicate all of the enzymatic reaction, and expression of "CHST10".