GGDB:

CHST11は、carbohydrate (chondroitin 4) sulfotransferase 11をコードする。この酵素はGAGの1種であるコンドロイチン硫酸の生合成に関与する。コンドロイチン硫酸は（GalNAcβ1,4GlcAβ1,3）の2糖の繰り返し構造であるが、CHST11はGalNAcの4位に硫酸を転移するC4ST活性を有する。ヒトでは3種類のイソ酵素（CHST11, CHST12,CHST13）が存在する。CHST11のノックアウトマウスは成長板軟骨細胞のカラム構造の構築不全による軟骨異形成を示す。

Keyword: コンドロイチン硫酸 , プロテオグリカン , 硫酸転移酵素

Sulfotransferases

GGDB Symbol

CHST11 Alias

Designation

chondroitin D-N-acetylgalactosamine-4-O-sulfotransferase

Organism

Homo sapiens

GeneID

50515

HGNC

CHST11 (17422)

mRNA

NM_018413

map

12q

Protein

NP_060883

EC#

2.8.2.5

CAZy

GlyCosmos Glycogenes

CHST11

OMIM

610128

Disease name

GDGDB

Human Protein Atlas

ENSG00000171310

Mus musculus

mRNA	NM_021439
Protein	NP_067414
MGI	48764

Rattus norvegicus

mRNA	XM_235007
Protein	XP_235007

Drosophila melanogaster

mRNA	NM_135076
Protein	NP_608920

J Biol Chem 2000-03-01 ;275(12):8975-81.

Molecular cloning and expression of chondroitin 4-sulfotransferase.

Yamauchi S. et al. PMID:10722746

J Biochem 2000-06-01 ;275(26):20188-96.

Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family.

Hiraoka N. et al. PMID:10781601

J. Biol. Chem. 2000-11-01 ;128(5):763-70.

Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase.

Okuda T. et al. PMID:11056388

J Biol Chem 2001-09-01 ;276(39):36344-53.

Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.

Evers MR. et al. PMID:11470797

table 1
Glycoprotein	Enzyme activity
Chondroitin (medium)	2266
Dermatan (medium)	448

J Biol Chem 2002-09-01 ;277(38):34766-72.

Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases.

Kang HG. et al. PMID:12080076 Refer to: TABLE I

DONOR : PAPS

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR029199 GlyTouCan: G71793UG GlyCosmos Glycans: G71793UG	PAPS	JCGG-STR029465 GlyTouCan: G00547ZN GlyCosmos Glycans: G00547ZN

table 1
Glycoprotein	Enzyme activity
Chondroitin	1054
Dermatan	143

J Biol Chem 2003-09-01 ;278(38):36115-27.

Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis.

Mikami T. et al. PMID:12847091

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J Biol Chem 2000-03-01 ;275(12):8975-81.

Molecular cloning and expression of chondroitin 4-sulfotransferase.

Yamauchi S. et al. PMID:10722746

J Biochem 2000-06-01 ;275(26):20188-96.

Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family.

Hiraoka N. et al. PMID:10781601

J. Biol. Chem. 2000-11-01 ;128(5):763-70.

Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase.

Okuda T. et al. PMID:11056388

bone marrowlunglymph nodeperipheral blood leukocyteplacentaspleenthymus

Provided by GOA

Function
N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
N-acetylgalactosamine 4-O-sulfotransferase activity
chondroitin 4-sulfotransferase activity

Process
carbohydrate biosynthetic process
chondrocyte development
chondroitin sulfate biosynthetic process
developmental growth
embryonic digit morphogenesis
embryonic viscerocranium morphogenesis
negative regulation of transforming growth factor beta receptor signaling pathway
negative regulation of apoptotic process
polysaccharide localization
post-anal tail morphogenesis
post-embryonic development
regulation of cell proliferation
respiratory gaseous exchange

Component
Golgi membrane
integral component of membrane
membrane

CHST11

Sulfotransferases

Orthologous Gene

Mus musculus

Rattus norvegicus

Drosophila melanogaster

Acceptor Substrates (Reference)

Molecular cloning and expression of chondroitin 4-sulfotransferase.

Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family.

Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase.

Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.

Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases.

DONOR : PAPS

Substrate Transferred

Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning and expression of chondroitin 4-sulfotransferase.

Molecular cloning and expression of two distinct human chondroitin 4-O-sulfotransferases that belong to the HNK-1 sulfotransferase gene family.

Molecular cloning, expression, and chromosomal mapping of human chondroitin 4-sulfotransferase, whose expression pattern in human tissues is different from that of chondroitin 6-sulfotransferase.

Gene Ontology