GGDB:

CHST13 encodes carbohydrate (chondroitin 4) sulfotransferase 13. This enzyme has C4ST activity to transfer sulfate to position 4 of GalNAc in the chondroitin sulfate biosynthesis. In human, there are three isoenzymes (CHST11, CHST12, CHST13). CHST13 mRNA is particularly highly expressed in adult liver, followed by adult kidney, lymph nodes, and fetal liver.

Keyword: chondroitin sulfate , proteoglycan , sulfotransferase

Sulfotransferases

GGDB Symbol

CHST13 Alias

Designation

chondroitin D-N-acetylgalactosamine-4-O-sulfotransferase 3

Organism

Homo sapiens

GeneID

166012

HGNC

CHST13 (21755)

mRNA

NM_152889

map

3q21.3

Protein

NP_690849

EC#

2.8.2.5

CAZy

GlyCosmos Glycogenes

CHST13

OMIM

610124

Disease name

GDGDB

Human Protein Atlas

ENSG00000180767

Mus musculus

mRNA	XM_355798
Protein	XP_355798

Rattus norvegicus

mRNA	XM_575606
Protein	XP_575606

Drosophila melanogaster

mRNA	NM_135976
Protein	NP_609820

J. Biol. Chem. 2002-09-01 ;277(38):34766-72.

Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases.

Kang HG. et al. PMID:12080076 Refer to: TABLE I

DONOR : PAPS

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR029199 GlyTouCan: G71793UG GlyCosmos Glycans: G71793UG	PAPS	JCGG-STR029465 GlyTouCan: G00547ZN GlyCosmos Glycans: G00547ZN

table 1
Glycoprotein	Enzyme activity
Chondroitin	195
Dermatan	47

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 2002-09-01 ;277(38):34766-72.

Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases.

Kang HG. et al. PMID:12080076

fetal liverkidneyliverlymph node

Provided by GOA

Function
N-acetylgalactosamine 4-O-sulfotransferase activity
chondroitin 4-sulfotransferase activity

Process
carbohydrate biosynthetic process
chondroitin sulfate biosynthetic process

Component
Golgi membrane
integral component of membrane

CHST13

Sulfotransferases

Orthologous Gene

Mus musculus

Rattus norvegicus

Drosophila melanogaster

Acceptor Substrates (Reference)

Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases.

DONOR : PAPS

Substrate Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases.

Gene Ontology