GGDB:

UST encodes uronyl-2-sulfotransferase, which transfers sulfate to the C2-position of the uronyl group in the glucuronic acid of chondroitin sulfate and the isuronic acid of dermatan sulfate. UST shows significant sequence homology to HS2ST, a glucuronide/isuronic acid sulfatase at C2-position in heparan sulfate.

Keyword: chondroitin , chondroitin sulfate , proteoglycan , sulfotransferase

Sulfotransferases

GGDB Symbol

UST Alias

Designation

dermatan/chondroitin sulfate 2-O-sulfotransferase

Organism

Homo sapiens

GeneID

10090

HGNC

UST (17223)

mRNA

NM_005715

map

6q25.1

Protein

NP_005706

EC#

CAZy

GlyCosmos Glycogenes

UST

OMIM

610752

Disease name

GDGDB

Human Protein Atlas

ENSG00000111962

Mus musculus

mRNA	NM_177387
Protein	NP_796361
MGI	83654

Rattus norvegicus

mRNA	XM_341729
Protein	XP_341728

J. Biol. Chem. 1999-04-01 ;274(15):10474-80.

Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate.

Kobayashi M. et al. PMID:10187838

TABLE I
Glycoprotein	Enzyme activity
Dermatan sulfate	3400
Dermatan (chemically desulfated dermatan sulfate with small amount of residual 4-sulfate)	1500
CDSNS-heparin (completely desulfated N-resulfated heparin)	1250
Chondroitin sulfate C (Seikagaku; 90% 6-sulfate, 10% 4-sulfate)	250
Chondroitin	45

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 1999-04-01 ;274(15):10474-80.

Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate.

Kobayashi M. et al. PMID:10187838

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Provided by GOA

Function
sulfotransferase activity

Process
dermatan sulfate biosynthetic process
establishment of cell polarity
protein sulfation
regulation of axonogenesis

Component
Golgi membrane
integral component of membrane

UST

Sulfotransferases

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning and characterization of a human uronyl 2-sulfotransferase that sulfates iduronyl and glucuronyl residues in dermatan/chondroitin sulfate.

Gene Ontology