GGDB:

CHST14 encodes carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 14. This enzyme is involved in the biosynthesis of dermatan sulfate. Delmathan sulfate is a repeating disaccharide structure of (GalNAcβ1,4IdoAβ1,3), and CHST14 has D4ST activity to transfer sulfate to position 4 of GalNAc. CHST14 is the causative gene of Ehlers-Danlos syndrome (kosho type).

Keyword: dermatan sulfate , sulfotransferase

Sulfotransferases

GGDB Symbol

CHST14 Alias

Designation

dermatan-4-sulfotransferase-1

Organism

Homo sapiens

GeneID

113189

HGNC

CHST14 (24464)

mRNA

NM_130468

map

15q15.1

Protein

NP_569735

EC#

CAZy

GlyCosmos Glycogenes

CHST14

OMIM

608429

Disease name

GDGDB

Human Protein Atlas

ENSG00000169105

Mus musculus

mRNA	NM_028117
Protein	NP_082393
MGI	56116

J Biol Chem 2001-09-01 ;276(39):36344-53.

Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.

Evers MR. et al. PMID:11470797

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Not Transferred

	JCGG-STR007574 GlyTouCan: G10271ZL GlyCosmos Glycans: G10271ZL

	JCGG-STR029199 GlyTouCan: G71793UG GlyCosmos Glycans: G71793UG

table 1
Glycoprotein	Enzyme activity
Dermatan (medium)	3396
Chondroitin (medium)	346

J Biol Chem 2002-09-01 ;277(38):34766-72.

Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases.

Kang HG. et al. PMID:12080076 Refer to: TABLE I

DONOR : PAPS

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR029199 GlyTouCan: G71793UG GlyCosmos Glycans: G71793UG	PAPS	JCGG-STR029465 GlyTouCan: G00547ZN GlyCosmos Glycans: G00547ZN

table 1
Glycoprotein	Enzyme activity
Dermatan	1156
Chondroitin	89

J. Biol. Chem. 2003-09-01 ;278(38):36115-27.

Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis.

Mikami T. et al. PMID:12847091

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J Biol Chem 2001-09-01 ;276(39):36344-53.

Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.

Evers MR. et al. PMID:11470797

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Provided by GOA

Function
N-acetylgalactosamine 4-O-sulfotransferase activity
phosphate ion binding

Process
carbohydrate biosynthetic process
dermatan sulfate biosynthetic process
dermatan sulfate proteoglycan metabolic process

Component
Golgi membrane
extracellular exosome
integral component of membrane

CHST14

Sulfotransferases

Orthologous Gene

Mus musculus

Acceptor Substrates (Reference)

Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.

Substrate Not Transferred

Molecular cloning and characterization of chondroitin-4-O-sulfotransferase-3. A novel member of the HNK-1 family of sulfotransferases.

DONOR : PAPS

Substrate Transferred

Specificities of three distinct human chondroitin/dermatan N-acetylgalactosamine 4-O-sulfotransferases demonstrated using partially desulfated dermatan sulfate as an acceptor: implication of differential roles in dermatan sulfate biosynthesis.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning and characterization of a dermatan-specific N-acetylgalactosamine 4-O-sulfotransferase.

Gene Ontology