GAL3ST4

Galactose-3-O-sulfotranasferases 4 (GAL3ST4) was cloned as a protein β-Gal 3'-sulfotransferase, which transfers a sulfate group from the donor substrate (PAPS), to the C3 position of the nonreducing termina β-Gal residue on O-linked glycans. GAL3ST4 cannot act onglycolipids, and recognizes core 1 O-glycan Galβ1→3GalNAc and Galβ1→3(GlcNAcβ1→6)GalNAc as good acceptors, but not Galβ1→3/4GlcNAc.