ST3GAL1

Last Update:2016-01-29

ST3GAL1もしくはβ-ガラクシドα-2,3-シアリルトランスフェラーゼ1は、ムチン型O-グリカンの主要なコア構造であるコア１ O-グリカンGalβ1→3GalNAc→Ser/Thrへのシアリル酸付加を触媒する。ST3GAL1は以前はST3OやSIAT4Aとして知られていた。ST3GAL1欠損マウスおよび改変マウスはコア1 O-グリカンのシアリル酸付加がTリンパ球の恒常性維持に必要であることを示した。

Keyword: CMP-シアリル酸 , GCNT1 , コア1 O-グリカン , シアリルT抗原 , 胸腺

	CMP-Neu5Ac
JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO		JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

Sialyltransferase

GGDB Symbol

ST3GAL1 Alias

Designation

CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase I

Organism

Homo sapiens

GeneID

HGNC

ST3GAL1 (10862)

mRNA

map

8q24.22

Protein

EC#

2.4.99.4

CAZy

GT29

GlyCosmos Glycogenes

ST3GAL1

OMIM

607187

Disease name

GDGDB

Human Protein Atlas

ENSG00000008513

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Orthologous Gene

Mus musculus

mRNA	NM_009177
Protein	NP_033203
MGI	13441

Rattus norvegicus

mRNA	XM_343255
Protein	XP_343255

Acceptor Substrates (Reference)

J. Biol. Chem. 1994-07-01 ;269(27):17872-8.

Differential expression of five sialyltransferase genes in human tissues.

Kitagawa H. et al. PMID:8027041 Refer to: TABLE I

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	CMP-Neu5Ac	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

	JCGG-STR027464 GlyTouCan: G21856LC GlyCosmos Glycans: G21856LC	CMP-Neu5Ac	JCGG-STR031354 GlyTouCan: G03277YI GlyCosmos Glycans: G03277YI

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	CMP-Neu5Ac	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	CMP-Neu5Ac	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

	JCGG-STR002614 GlyTouCan: G48558GR GlyCosmos Glycans: G48558GR	CMP-Neu5Ac	JCGG-STR024659 GlyTouCan: G46677TE GlyCosmos Glycans: G46677TE

Substrate Not Transferred

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

J. Biol. Chem. 1994-01-01 ;269(2):1394-401.

Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups.

Kitagawa H. et al. PMID:8288606 Refer to: TABLE I

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	CMP-Neu5Ac	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO	CMP-Neu5Ac	JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO	CMP-Neu5Ac	JCGG-STR031358 GlyTouCan: G79536OW GlyCosmos Glycans: G79536OW

Substrate Not Transferred

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ

	JCGG-STR007014 GlyTouCan: G26123AX GlyCosmos Glycans: G26123AX

	JCGG-STR027035 GlyTouCan: G72002FC GlyCosmos Glycans: G72002FC

TABLE II Comparison of acceptor specificity of STZ, ST30, and ST3N
Acceptor	Relative rate (%)
Antifreeze glycoprotein	57
Asialofetuin	26
Ovine submaxillary asialomucin	5
Asialo-[alpha]1-acid glycoprotein	0

Acceptor Substrates (KEM-C)

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

		CMP-Neu5Ac
	JCGG-STR029201 GlyTouCan: G00033MO GlyCosmos Glycans: G00033MO		JCGG-STR004668 GlyTouCan: G85608AG GlyCosmos Glycans: G85608AG

		CMP-Neu5Ac
	JCGG-STR004625 GlyTouCan: G11647UD GlyCosmos Glycans: G11647UD		JCGG-STR031461 GlyTouCan: G51162XR GlyCosmos Glycans: G51162XR

Expression

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

J. Biol. Chem. 1994-07-01 ;269(27):17872-8.

Differential expression of five sialyltransferase genes in human tissues.

Kitagawa H. et al. PMID:8027041

colonfetal brainfetal heartfetal kidneyfetal liverfetal lungheartkidneyliverlungovarypancreasperipheral blood leukocyteplacentaprostateskeletal musclesmall intestinespleenthymus

Gene Ontology

Provided by GOA

Function
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

Process
N-acetylneuraminate metabolic process
O-glycan processing
cellular protein modification process
ganglioside biosynthetic process
keratan sulfate biosynthetic process
keratan sulfate synthesis
oligosaccharide metabolic process
protein N-linked glycosylation
protein N-linked glycosylation via asparagine
protein phosphorylation
sialylation

Component
Golgi cisterna membrane
Golgi membrane
extracellular exosome
integral component of Golgi membrane
membrane

This page does not indicate all of the enzymatic reaction, and expression of "ST3GAL1".