GGDB:

ST3GAL2, β-galactoside α-2,3-sialyltransferase 2, transfers sialic acid from CMP-sialic acid to the Galβ1→3GalNAc-R as an acceptor substrate, which are found in glycolipids, such as GM1 and GD1b. ST3GAL2 is also known as SIAT4B. ST3GAL2 is highly expressed in mouse brain and ST3GAL2-deficient mice show decrease of GD1a and GT1b.

Keyword:

	CMP-Neu5Ac
JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO		JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

Sialyltransferase

GGDB Symbol

ST3GAL2 Alias

Designation

CMP-NeuAc:beta-galactoside alpha-2,3-sialyltransferase II

Organism

Homo sapiens

GeneID

6483

HGNC

ST3GAL2 (10863)

mRNA

NM_006927

map

16q22.1

Protein

NP_008858

EC#

2.4.99.4

CAZy

GT29

GlyCosmos Glycogenes

ST3GAL2

OMIM

607188

Disease name

GDGDB

Human Protein Atlas

ENSG00000157350

Mus musculus

mRNA	NM_009179
Protein	NP_033205
MGI	15226

Rattus norvegicus

mRNA	NM_031695
Protein	NP_113883

Biochem. Biophys. Res. Commun. 1996-11-01 ;228(2):324-7.

Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II).

Kim YJ. et al. PMID:8920913 Refer to: TABLE 1

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR027464 GlyTouCan: G21856LC GlyCosmos Glycans: G21856LC	CMP-Neu5Ac	JCGG-STR027271 GlyTouCan: G03277YI GlyCosmos Glycans: G03277YI

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	CMP-Neu5Ac	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

	JCGG-STR002614 GlyTouCan: G48558GR GlyCosmos Glycans: G48558GR	CMP-Neu5Ac	JCGG-STR024659 GlyTouCan: G46677TE GlyCosmos Glycans: G46677TE

Eur. J. Biochem. 1997-07-01 ;247(2):558-66.

Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line.

Giordanengo V. et al. PMID:9266697 Refer to: Table 1

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	CMP-Neu5Ac	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Biochem. Biophys. Res. Commun. 2003-01-01 ;300(2):570-6.

Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene.

Taniguchi A. et al. PMID:12504121

Biochem. Biophys. Res. Commun. 1996-11-01 ;228(2):324-7.

Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II).

Kim YJ. et al. PMID:8920913

Eur. J. Biochem. 1997-07-01 ;247(2):558-66.

Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line.

Giordanengo V. et al. PMID:9266697

brainheartkidneyliverlungovarypancreasplacentaprostateskeletal musclesmall intestinespleentestisthymus

Provided by GOA

Function
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity

Process
O-glycan processing
amino sugar metabolic process
cellular protein modification process
ganglioside biosynthetic process
keratan sulfate biosynthetic process
keratan sulfate synthesis
oligosaccharide metabolic process
protein N-linked glycosylation via asparagine
sialylation

Component
Golgi cisterna membrane
Golgi membrane
extracellular region
integral component of Golgi membrane

ST3GAL2

Sialyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II).

DONOR : CMP-Neu5Ac

Substrate Transferred

Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line.

DONOR : CMP-Neu5Ac

Substrate Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Genomic structure, expression, and transcriptional regulation of human Gal beta 1,3 GalNAc alpha 2,3-sialyltransferase gene.

Molecular cloning and expression of human Gal beta 1,3GalNAc alpha 2,3-sialytransferase (hST3Gal II).

Cloning and expression of cDNA for a human Gal(beta1-3)GalNAc alpha2,3-sialyltransferase from the CEM T-cell line.

Gene Ontology