GGDB:

ST3GAL3、β-ガラクトシドα-2,3-シアリルトランスフェラーゼ3は、シアリル酸をCMP-シアリル酸からGalβ1→3/4GlcNAc-Rへ転移する。ST3GAL3はST3NもしくはSIAT6としても知られている。ST3GAL3はシアリルルイスa (NeuAcα2→3Galb1→3(Fucα1→4)GlcNAc-R) の合成に関わっている。ST3GAL3遺伝子のホモ接合変異は精神発達遅滞を引き起こすと示唆されている。

Keyword:

	CMP-Neu5Ac
JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO		JCGG-STR031358 GlyTouCan: G79536OW GlyCosmos Glycans: G79536OW

	CMP-Neu5Ac
JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO		JCGG-STR031527 GlyTouCan: G00065MO GlyCosmos Glycans: G00065MO

Sialyltransferase

GGDB Symbol

ST3GAL3 Alias

Designation

CMP-NeuAc:Gal beta1,3(4)GlcNAc alpha 2,3-sialyltransferase

Organism

Homo sapiens

GeneID

6487

HGNC

ST3GAL3 (10866)

mRNA

NM_006279

map

1p34.1

Protein

NP_006270

EC#

2.4.99.6

CAZy

GT29

GlyCosmos Glycogenes

ST3GAL3

OMIM

606494

Disease name

GDGDB

Human Protein Atlas

ENSG00000126091

Mus musculus

mRNA	NM_009176
Protein	NP_033202
MGI	38605

Rattus norvegicus

mRNA	NM_031697
Protein	NP_113885

J. Biol. Chem. 1994-01-01 ;269(2):1394-401.

Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups.

Kitagawa H. et al. PMID:8288606 Refer to: TABLE I

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO	CMP-Neu5Ac	JCGG-STR031358 GlyTouCan: G79536OW GlyCosmos Glycans: G79536OW

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO	CMP-Neu5Ac	JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	CMP-Neu5Ac	JCGG-STR031527 GlyTouCan: G00065MO GlyCosmos Glycans: G00065MO

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW	CMP-Neu5Ac	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	CMP-Neu5Ac	JCGG-STR031363 GlyTouCan: G01767JJ GlyCosmos Glycans: G01767JJ

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	CMP-Neu5Ac	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

Substrate Not Transferred

	JCGG-STR007014 GlyTouCan: G26123AX GlyCosmos Glycans: G26123AX

	JCGG-STR027035 GlyTouCan: G72002FC GlyCosmos Glycans: G72002FC

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO

TABLE II Comparison of acceptor specificity of STZ, ST30, and ST3N
Acceptor	Relative rate (%)
Asialofetuin	17
Asialo-[alpha]1-acid glycoprotein	14
Ovine submaxillary asialomucin	1

Biochem. Biophys. Res. Commun. 1993-07-01 ;194(1):375-82.

Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase.

Kitagawa H. et al. PMID:8333853 Refer to: Table 1

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO	CMP-Neu5Ac	JCGG-STR031358 GlyTouCan: G79536OW GlyCosmos Glycans: G79536OW

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

		CMP-Neu5Ac
	JCGG-STR027300 GlyTouCan: G32723SL GlyCosmos Glycans: G32723SL		JCGG-STR031464 GlyTouCan: G64844ET GlyCosmos Glycans: G64844ET

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Biochem. Biophys. Res. Commun. 1994-07-01 ;269(27):17872-8.

Differential expression of five sialyltransferase genes in human tissues.

Kitagawa H. et al. PMID:8027041

Biochem. Biophys. Res. Commun. 1993-07-01 ;194(1):375-82.

Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase.

Kitagawa H. et al. PMID:8333853

braincolonfetal brainfetal heartfetal kidneyfetal liverfetal lungheartovaryprostateskeletal musclesmall intestinespleentestis

ST3GAL3

Sialyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups.

DONOR : CMP-Neu5Ac

Substrate Transferred

Substrate Not Transferred

Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase.

DONOR : CMP-Neu5Ac

Substrate Transferred

Acceptor Substrates (KEM-C)

DONOR : CMP-Neu5Ac

Substrate Transferred

Expression

Expression (Reference)

Differential expression of five sialyltransferase genes in human tissues.

Cloning and expression of human Gal beta 1,3(4)GlcNAc alpha 2,3-sialyltransferase.

Gene Ontology