GGDB:

ST3GAL4, β-galactoside α-2,3-sialyltransferase 4, transfers sialic acid from CMP-sialic acid to the Galβ1→3GalNAc/Galβ1→4GlcNAc-R on glycoproteins. ST3GAL4 is also known as STZ, ST3O/N, ST-4 or SIAT4C. ST3GAL4-deficient mice presented reduction in plasma von Willebrand factor and suggest that ST3GAL4 is involved in platelet clearance through the Ashwell receptor.

Keyword:

	CMP-Neu5Ac
JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO		JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

	CMP-Neu5Ac
JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ		JCGG-STR031363 GlyTouCan: G01767JJ GlyCosmos Glycans: G01767JJ

Sialyltransferase

GGDB Symbol

ST3GAL4 Alias

Designation

Gal-beta(1-3/1-4)GlcNAc alpha-2.3-sialyltransferase

Organism

Homo sapiens

GeneID

6484

HGNC

ST3GAL4 (10864)

mRNA

NM_006278

map

11q23-q24

Protein

NP_006269

EC#

2.4.99.6

CAZy

GT29

GlyCosmos Glycogenes

ST3GAL4

OMIM

104240

Disease name

GDGDB

Human Protein Atlas

ENSG00000110080

Mus musculus

mRNA	NM_009178
Protein	NP_033204
MGI	38683

Rattus norvegicus

mRNA	NM_203337
Protein	NP_976082

J. Biol. Chem. 1994-01-01 ;269(2):1394-401.

Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups.

Kitagawa H. et al. PMID:8288606 Refer to: TABLE I

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	CMP-Neu5Ac	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	CMP-Neu5Ac	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	CMP-Neu5Ac	JCGG-STR031363 GlyTouCan: G01767JJ GlyCosmos Glycans: G01767JJ

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	CMP-Neu5Ac	JCGG-STR031527 GlyTouCan: G00065MO GlyCosmos Glycans: G00065MO

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW	CMP-Neu5Ac	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK

Substrate Not Transferred

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO

	JCGG-STR007014 GlyTouCan: G26123AX GlyCosmos Glycans: G26123AX

	JCGG-STR027035 GlyTouCan: G72002FC GlyCosmos Glycans: G72002FC

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

TABLE II Comparison of acceptor specificity of STZ, ST30, and ST3N
Acceptor	Relative rate (%)
Asialofetuin	92
Asialo-[alpha]1-acid glycoprotein	51
Ovine submaxillary asialomucin	4

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

		CMP-Neu5Ac
	JCGG-STR025848 GlyTouCan: G64973KT GlyCosmos Glycans: G64973KT		JCGG-STR027483 GlyTouCan: G11457RF GlyCosmos Glycans: G11457RF

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 1993-10-01 ;268(30):22782-7.

Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection.

Sasaki K. et al. PMID:7901202

J. Biol. Chem. 1994-07-01 ;269(27):17872-8.

Differential expression of five sialyltransferase genes in human tissues.

Kitagawa H. et al. PMID:8027041

J. Biol. Chem. 1994-01-01 ;269(2):1394-401.

Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups.

Kitagawa H. et al. PMID:8288606

braincolonfetal brainfetal heartfetal kidneyfetal liverfetal lungheartkidneyliverlungovaryperipheral blood leukocyteplacentaprostateskeletal musclesmall intestinespleentestisthymus

Provided by GOA

Function
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
monosialoganglioside sialyltransferase activity

Process
O-glycan processing
cognition
ganglioside biosynthetic process
keratan sulfate biosynthetic process
keratan sulfate synthesis
oligosaccharide metabolic process
protein N-linked glycosylation via asparagine
sialylation

Component
Golgi cisterna membrane
Golgi membrane
extracellular exosome
integral component of Golgi membrane
membrane

ST3GAL4

Sialyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups.

DONOR : CMP-Neu5Ac

Substrate Transferred

Substrate Not Transferred

Acceptor Substrates (KEM-C)

DONOR : CMP-Neu5Ac

Substrate Transferred

Expression

Expression (Reference)

Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection.

Differential expression of five sialyltransferase genes in human tissues.

Cloning of a novel alpha 2,3-sialyltransferase that sialylates glycoprotein and glycolipid carbohydrate groups.

Gene Ontology