GGDB:

ST3GAL6, β-galactoside α-2,3-sialyltransferase 6, transfers sialic acid from CMP-sialic acid to the Galβ1→4GlcNAc structure on glycoproteins and glycolipids. ST3GAL6 is also called as SIAT10. ST3GAL6 utilizes the Galβ1→4GlcNAc on asialofetuin, neolactotetraosylceramide (nLc4) and neolactohexaosylceramide (nLc6), but not lactosylceramide. ST3GAL6-deficient mice demonstrated that ST3GAL6 and ST3GAL4 are required for the synthesis and function of the selectin ligands.

Keyword: glycolipid , sialyl Lewis X , sialyl-paragloboside

	CMP-Neu5Ac
JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO		JCGG-STR014102 GlyTouCan: G00065MO GlyCosmos Glycans: G00065MO

	CMP-Neu5Ac
JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO		JCGG-STR014102 GlyTouCan: G00065MO GlyCosmos Glycans: G00065MO

Sialyltransferase

GGDB Symbol

ST3GAL6 Alias

Designation

CMP-NeuAc:alpha-2,3-sialyltransferase

Organism

Homo sapiens

GeneID

10402

HGNC

ST3GAL6 (18080)

mRNA

NM_006100

map

3q12.

Protein

NP_006091

EC#

2.4.99.10

CAZy

GT29

GlyCosmos Glycogenes

ST3GAL6

OMIM

607156

Disease name

GDGDB

Human Protein Atlas

ENSG00000064225

Mus musculus

mRNA	NM_018784
Protein	NP_061254
MGI	47534

Rattus norvegicus

mRNA	NM_207602
Protein	NP_997485

J. Biol. Chem. 1999-04-01 ;274(17):11479-86.

Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids.

Okajima T. et al. PMID:10206952 Refer to: TABLE I

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR026436 GlyTouCan: G84034JH GlyCosmos Glycans: G84034JH	CMP-Neu5Ac	JCGG-STR027219 GlyTouCan: G03067VG GlyCosmos Glycans: G03067VG

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	CMP-Neu5Ac	JCGG-STR027108 GlyTouCan: G01767JJ GlyCosmos Glycans: G01767JJ

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	CMP-Neu5Ac	JCGG-STR014102 GlyTouCan: G00065MO GlyCosmos Glycans: G00065MO

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	CMP-Neu5Ac	JCGG-STR014102 GlyTouCan: G00065MO GlyCosmos Glycans: G00065MO

Substrate Not Transferred

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK

	JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT

	JCGG-STR002614 GlyTouCan: G48558GR GlyCosmos Glycans: G48558GR

	JCGG-STR024659 GlyTouCan: G46677TE GlyCosmos Glycans: G46677TE

	JCGG-STR024670 GlyTouCan: G37184KW GlyCosmos Glycans: G37184KW

	JCGG-STR031351 GlyTouCan: G40183QN GlyCosmos Glycans: G40183QN

	JCGG-STR004466 GlyTouCan: G18625KA GlyCosmos Glycans: G18625KA

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR027464 GlyTouCan: G21856LC GlyCosmos Glycans: G21856LC

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO

	JCGG-STR027035 GlyTouCan: G72002FC GlyCosmos Glycans: G72002FC

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

TABLE I Acceptor substrate specificity of ST3 Gal VI
Acceptor	Relative rate (%)
Asialofetuin	22
Asialo-BSM	0

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 1999-04-01 ;274(17):11479-86.

Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids.

Okajima T. et al. PMID:10206952

brainheartkidneyliverpancreasplacentaskeletal muscle

ST3GAL6

Sialyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids.

DONOR : CMP-Neu5Ac

Substrate Transferred

Substrate Not Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning of a novel alpha2,3-sialyltransferase (ST3Gal VI) that sialylates type II lactosamine structures on glycoproteins and glycolipids.

Gene Ontology