ST6GAL1

Last Update:2016-01-29

ST6GAL1, β-galactoside α-2,6-sialyltransferase 1, transfers sialic acid from CMP-sialic acid to the Galβ1→4GlcNAc structure on glycoproteins, such as asialofetuin and asialo-a1-acid glycoprotein. ST6GAL1 is also called as ST6N or SIAT1. ST6GAL1-deficient mice demonstrated that ST6GAL1 and its products are required for promoting B lymphocyte activation.

Keyword:

	CMP-Neu5Ac
JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ		JCGG-STR031353 GlyTouCan: G83513YI GlyCosmos Glycans: G83513YI

	CMP-Neu5Ac
JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO		JCGG-STR031552 GlyTouCan: G73578JC GlyCosmos Glycans: G73578JC

Sialyltransferase

GGDB Symbol

ST6GAL1 Alias

Designation

CMP-NeuAc:galactoside alpha-2,6-sialyltransferase

Organism

Homo sapiens

GeneID

HGNC

ST6GAL1 (10860)

mRNA

map

3q27-q28

Protein

EC#

2.4.99.1

CAZy

GT29

GlyCosmos Glycogenes

ST6GAL1

OMIM

109675

Disease name

GDGDB

Human Protein Atlas

ENSG00000073849

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Orthologous Gene

Mus musculus

mRNA	NM_145933
Protein	NP_666045
MGI	30059

Rattus norvegicus

mRNA	NM_147205
Protein	NP_671738

Acceptor Substrates (Reference)

J. Biol. Chem. 2002-11-01 ;277(48):45719-28.

Characterization of the second type of human beta-galactoside alpha 2,6-sialyltransferase (ST6Gal II), which sialylates Galbeta 1,4GlcNAc structures on oligosaccharides preferentially. Genomic analysis of human sialyltransferase genes.

Takashima S. et al. PMID:12235148 Refer to: TABLE I

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	CMP-Neu5Ac	JCGG-STR031353 GlyTouCan: G83513YI GlyCosmos Glycans: G83513YI

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO	CMP-Neu5Ac	JCGG-STR031554 GlyTouCan: G48838EV GlyCosmos Glycans: G48838EV

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW	CMP-Neu5Ac	JCGG-STR025514 GlyTouCan: G28868ZC GlyCosmos Glycans: G28868ZC

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	CMP-Neu5Ac	JCGG-STR031353 GlyTouCan: G83513YI GlyCosmos Glycans: G83513YI

Substrate Not Transferred

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

	JCGG-STR027464 GlyTouCan: G21856LC GlyCosmos Glycans: G21856LC

	JCGG-STR002614 GlyTouCan: G48558GR GlyCosmos Glycans: G48558GR

	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK

Eur. J. Biochem. 2003-03-01 ;270(5):950-61.

Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II.

Krzewinski-Recchi MA. et al. PMID:12603328 Refer to: Table 1.

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	CMP-Neu5Ac	JCGG-STR031353 GlyTouCan: G83513YI GlyCosmos Glycans: G83513YI

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	CMP-Neu5Ac	JCGG-STR031552 GlyTouCan: G73578JC GlyCosmos Glycans: G73578JC

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	CMP-Neu5Ac	JCGG-STR031552 GlyTouCan: G73578JC GlyCosmos Glycans: G73578JC

Substrate Not Transferred

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO

Table 1. Comparison of the acceptor substrate specificity of ST6Gal I and ST6Gal II.
Acceptor	Relative rate (%)
Asialo-[alpha]1-acid glycoprotein	100
Asialofetuin	83
Fetuin	1
[alpha]1-acid glycoprotein	0

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

J. Biol. Chem. 2002-11-01 ;277(48):45719-28.

Characterization of the second type of human beta-galactoside alpha 2,6-sialyltransferase (ST6Gal II), which sialylates Galbeta 1,4GlcNAc structures on oligosaccharides preferentially. Genomic analysis of human sialyltransferase genes.

Takashima S. et al. PMID:12235148

Eur. J. Biochem. 2003-03-01 ;270(5):950-61.

Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II.

Krzewinski-Recchi MA. et al. PMID:12603328

J. Biol. Chem. 1994-07-01 ;269(27):17872-8.

Differential expression of five sialyltransferase genes in human tissues.

Kitagawa H. et al. PMID:8027041

braincolonfetal brainfetal heartfetal kidneyfetal liverfetal lungfetal skeletal musclefetal spleenfetal thymusheartkidneyliverlungovarypancreasperipheral blood leukocyteprostateskeletal musclesmall intestinespleentestisthymus

Gene Ontology

Provided by GOA

Function
beta-galactoside alpha-2,6-sialyltransferase activity
protein binding
sialyltransferase activity

Process
N-acetylneuraminate metabolic process
O-glycan processing
humoral immune response
negative regulation of macrophage apoptotic process
negative regulation of chemotaxis
oligosaccharide metabolic process
positive regulation of mononuclear cell proliferation
protein N-linked glycosylation via asparagine
protein sialylation
regulation of substrate adhesion-dependent cell spreading
response to ethanol
sialylation

Component
Golgi cisterna membrane
Golgi medial cisterna
Golgi membrane
Golgi trans cisterna
endoplasmic reticulum
extracellular exosome
integral component of Golgi membrane

This page does not indicate all of the enzymatic reaction, and expression of "ST6GAL1".