ST6GAL2

Last Update:2016-01-29

ST6GAL2, β-galactoside α-2,6-sialyltransferase 2, transfers sialic acid from CMP-sialic acid to the Galβ1→4GlcNAc structure on glycoproteins, such as asialofetuin and asialo-a1-acid glycoprotein. ST6GAL2 is also called SIAT2. ST6GAL2 utilizes the Galβ1→4GlcNAc structure on glycoproteins and oligosaccharides as acceptor substrates as ST6GAL1 does. ST6GAL2 can utilize the GalNAcβ1→4GlcNAc (LacdiNAc) structure in contrast to ST6GAL1.

Keyword:

	CMP-Neu5Ac
JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ		JCGG-STR026960 GlyTouCan: G83513YI GlyCosmos Glycans: G83513YI

	CMP-Neu5Ac
JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO		JCGG-STR031552 GlyTouCan: G73578JC GlyCosmos Glycans: G73578JC

	CMP-Neu5Ac
JCGG-STR029533 GlyTouCan: G00057MO GlyCosmos Glycans: G00057MO		JCGG-STR030437 GlyTouCan: G54118CT GlyCosmos Glycans: G54118CT

Sialyltransferase

GGDB Symbol

ST6GAL2 Alias

Designation

CMP-NeuAc:galactoside alpha-2,6-sialyltransferase

Organism

Homo sapiens

GeneID

HGNC

ST6GAL2 (10861)

mRNA

map

2q11.2-q12.1

Protein

EC#

2.4.99.2

CAZy

GT29

GlyCosmos Glycogenes

ST6GAL2

OMIM

608472

Disease name

GDGDB

Human Protein Atlas

ENSG00000144057

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Orthologous Gene

Mus musculus

mRNA	NM_172829
Protein	NP_766417
MGI	86010

Rattus norvegicus

mRNA	XM_236826
Protein	XP_236826

Drosophila melanogaster

mRNA	NM_166684
Protein	NP_726474

Acceptor Substrates (Reference)

Biochim. Biophys. Acta 2002-11-01 ;277(48):45719-28.

Characterization of the second type of human beta-galactoside alpha 2,6-sialyltransferase (ST6Gal II), which sialylates Galbeta 1,4GlcNAc structures on oligosaccharides preferentially. Genomic analysis of human sialyltransferase genes.

Takashima S. et al. PMID:12235148 Refer to: Fig. 3 & Table I

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	CMP-Neu5Ac	JCGG-STR026960 GlyTouCan: G83513YI GlyCosmos Glycans: G83513YI

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	CMP-Neu5Ac	JCGG-STR031552 GlyTouCan: G73578JC GlyCosmos Glycans: G73578JC

	JCGG-STR029533 GlyTouCan: G00057MO GlyCosmos Glycans: G00057MO	CMP-Neu5Ac	JCGG-STR030437 GlyTouCan: G54118CT GlyCosmos Glycans: G54118CT

Substrate Not Transferred

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO

DNA Res. 2003-03-01 ;270(5):950-61.

Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II.

Krzewinski-Recchi MA. et al. PMID:12603328 Refer to: Table 1.

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	CMP-Neu5Ac	JCGG-STR031552 GlyTouCan: G73578JC GlyCosmos Glycans: G73578JC

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ	CMP-Neu5Ac	JCGG-STR031353 GlyTouCan: G83513YI GlyCosmos Glycans: G83513YI

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	CMP-Neu5Ac	JCGG-STR031552 GlyTouCan: G73578JC GlyCosmos Glycans: G73578JC

Substrate Not Transferred

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO

Table 1. Comparison of the acceptor substrate specificity of ST6Gal I and ST6Gal II.
Acceptor	Relative rate (%)
Asialo-[alpha]1-acid glycoprotein	100
Asialofetuin	66
[alpha]1-acid glycoprotein	0
Fetuin	0

DNA Res. 2006-04-01 ;1760(4):685-92.

Probing the substrate specificity of four different sialyltransferases using synthetic beta-D-Galp-(1-->4)-beta-D-GlcpNAc-(1-->2)-alpha-D-Manp-(1-->O) (CH(2))7CH3 analogues general activating effect of replacing N-acetylglucosamine by N-propionylglucosamine.

Rohfritsch PF. et al. PMID:16439063

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Biochim. Biophys. Acta 2001-04-01 ;8(2):85-95.

Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

Nagase T. et al. PMID:11347906

Biochim. Biophys. Acta 2002-11-01 ;277(48):45719-28.

Characterization of the second type of human beta-galactoside alpha 2,6-sialyltransferase (ST6Gal II), which sialylates Galbeta 1,4GlcNAc structures on oligosaccharides preferentially. Genomic analysis of human sialyltransferase genes.

Takashima S. et al. PMID:12235148

DNA Res. 2003-03-01 ;270(5):950-61.

Identification and functional expression of a second human beta-galactoside alpha2,6-sialyltransferase, ST6Gal II.

Krzewinski-Recchi MA. et al. PMID:12603328

braincolonfetal brainheartkidneyliverlungperipheral blood leukocyteplacentaskeletal musclesmall intestinespleenthymus

Gene Ontology

Provided by GOA

Function
beta-galactoside alpha-2,6-sialyltransferase activity

Process
growth
multicellular organism development
oligosaccharide metabolic process
protein N-linked glycosylation via asparagine
sialylation

Component
Golgi cisterna membrane
Golgi membrane
integral component of membrane

This page does not indicate all of the enzymatic reaction, and expression of "ST6GAL2".