ST6GALNAC2

Last Update:2016-01-29

ST6GALNAC2, N-acetylgalactosaminide α-2,6-sialyltransferase 2, transfers sialic acid from CMP-sialic acid to the Galβ1→3GalNAc-Ser/Thr structure on glycoproteins, such as fetuin and asialo-fetuin. ST6GALNAC2 is also called as SIAT7B. ST6GALNAC2 can utilize Galβl→3GalNAc-Ser/Thr and NeuAcα2→3Galβ1→3GalNAc-Ser/Thr as acceptor substrates.

Keyword:

	CMP-Neu5Ac
JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO		JCGG-STR026818 GlyTouCan: G56682BC GlyCosmos Glycans: G56682BC

	CMP-Neu5Ac
JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE		JCGG-STR026341 GlyTouCan: G01614ZM GlyCosmos Glycans: G01614ZM

Sialyltransferase

GGDB Symbol

ST6GALNAC2 Alias

Designation

GalNAc alpha-2, 6-sialyltransferase II

Organism

Homo sapiens

GeneID

HGNC

ST6GALNAC2 (10867)

mRNA

map

17q25.1

Protein

EC#

2.4.99.7

CAZy

GT29

GlyCosmos Glycogenes

OMIM

610137

Disease name

GDGDB

Human Protein Atlas

ENSG00000070731

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Orthologous Gene

Mus musculus

mRNA	NM_009180
Protein	NP_033206
MGI	41615

Rattus norvegicus

mRNA	XM_221134
Protein	XP_221134

Acceptor Substrates (Reference)

Biochim. Biophys. Acta 1999-11-01 ;9(11):1213-24.

Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens.

Ikehara Y. et al. PMID:10536037 Refer to: Table I.

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	CMP-Neu5Ac	JCGG-STR026818 GlyTouCan: G56682BC GlyCosmos Glycans: G56682BC

	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE	CMP-Neu5Ac	JCGG-STR026341 GlyTouCan: G01614ZM GlyCosmos Glycans: G01614ZM

Substrate Not Transferred

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

Glycobiology 2000-04-01 ;1474(2):201-11.

Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells.

Samyn-Petit B. et al. PMID:10742600 Refer to: Table 1

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	CMP-Neu5Ac	JCGG-STR026818 GlyTouCan: G56682BC GlyCosmos Glycans: G56682BC

	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE	CMP-Neu5Ac	JCGG-STR026341 GlyTouCan: G01614ZM GlyCosmos Glycans: G01614ZM

Substrate Not Transferred

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	JCGG-STR027464 GlyTouCan: G21856LC GlyCosmos Glycans: G21856LC

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

Table 1 Comparison of the acceptor substrate specificity of the three cloned ST6GalNAc II
Acceptor	Relative rate (%)
Asialofetuin	100
Fetuin	68
Asialo-BSM	12
BSM	11
OSM	0
Asialo-OSM	0
Asialo-[alpha]1-acid glycoprotein	0

Glycobiology 2000-11-01 ;352 Pt 1():37-48.

Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV.

Harduin-Lepers A. et al. PMID:11062056 Refer to: Table 1

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Not Transferred

	JCGG-STR002614 GlyTouCan: G48558GR GlyCosmos Glycans: G48558GR

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO

	JCGG-STR012166 GlyTouCan: G05212BT GlyCosmos Glycans: G05212BT

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR024659 GlyTouCan: G46677TE GlyCosmos Glycans: G46677TE

	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR027464 GlyTouCan: G21856LC GlyCosmos Glycans: G21856LC

	JCGG-STR031354 GlyTouCan: G03277YI GlyCosmos Glycans: G03277YI

	JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR

	JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR

	JCGG-STR031526 GlyTouCan: G64527IJ GlyCosmos Glycans: G64527IJ

	JCGG-STR031526 GlyTouCan: G64527IJ GlyCosmos Glycans: G64527IJ

	JCGG-STR031557 GlyTouCan: G41722LN GlyCosmos Glycans: G41722LN

table 1
Glycoprotein	Enzyme activity
Asialofetuin	131
Fetuin	100
Asialo-BSM	20
BSM	1
[alpha]1-acid glycoprotein	0
Asialo-[alpha]1-acid glycoprotein	0
OSM	0
Asialo-OSM	0

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Glycobiology 2000-04-01 ;1474(2):201-11.

Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells.

Samyn-Petit B. et al. PMID:10742600

heartkidneyliverskeletal musclesmall intestine

Gene Ontology

Provided by GOA

Function
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
sialyltransferase activity

Process
O-glycan processing
ganglioside biosynthetic process
oligosaccharide metabolic process
protein N-linked glycosylation via asparagine
sialylation

Component
Golgi membrane
integral component of Golgi membrane

This page does not indicate all of the enzymatic reaction, and expression of "ST6GALNAC2".