ST6GALNAC2

Last Update:2016-01-29

ST6GALNAC2, N-acetylgalactosaminide α-2,6-sialyltransferase 2, transfers sialic acid from CMP-sialic acid to the Galβ1→3GalNAc-Ser/Thr structure on glycoproteins, such as fetuin and asialo-fetuin. ST6GALNAC2 is also called as SIAT7B. ST6GALNAC2 can utilize Galβl→3GalNAc-Ser/Thr and NeuAcα2→3Galβ1→3GalNAc-Ser/Thr as acceptor substrates.

Keyword:

	CMP-Neu5Ac
JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO		JCGG-STR026818 GlyTouCan: G56682BC GlyCosmos Glycans: G56682BC

	CMP-Neu5Ac
JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE		JCGG-STR026341 GlyTouCan: G01614ZM GlyCosmos Glycans: G01614ZM

Sialyltransferase

GGDB Symbol

ST6GALNAC2 Alias

Designation

GalNAc alpha-2, 6-sialyltransferase II

Organism

Homo sapiens

GeneID

HGNC

ST6GALNAC2 (10867)

mRNA

map

17q25.1

Protein

EC#

2.4.99.7

CAZy

GT29

GlyCosmos Glycogenes

OMIM

610137

Disease name

GDGDB

Human Protein Atlas

ENSG00000070731

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Orthologous Gene

Mus musculus

mRNA	NM_009180
Protein	NP_033206
MGI	41615

Rattus norvegicus

mRNA	XM_221134
Protein	XP_221134

Acceptor Substrates (Reference)

Biochim. Biophys. Acta 1999-11-01 ;9(11):1213-24.

Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens.

Ikehara Y. et al. PMID:10536037 Refer to: Table I.

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	CMP-Neu5Ac	JCGG-STR026818 GlyTouCan: G56682BC GlyCosmos Glycans: G56682BC

	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE	CMP-Neu5Ac	JCGG-STR026341 GlyTouCan: G01614ZM GlyCosmos Glycans: G01614ZM

Substrate Not Transferred

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

Biochem. J. 2000-04-01 ;1474(2):201-11.

Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells.

Samyn-Petit B. et al. PMID:10742600 Refer to: Table 1

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	CMP-Neu5Ac	JCGG-STR026818 GlyTouCan: G56682BC GlyCosmos Glycans: G56682BC

	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE	CMP-Neu5Ac	JCGG-STR026341 GlyTouCan: G01614ZM GlyCosmos Glycans: G01614ZM

Substrate Not Transferred

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	JCGG-STR027464 GlyTouCan: G21856LC GlyCosmos Glycans: G21856LC

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

Table 1 Comparison of the acceptor substrate specificity of the three cloned ST6GalNAc II
Acceptor	Relative rate (%)
Asialofetuin	100
Fetuin	68
Asialo-BSM	12
BSM	11
OSM	0
Asialo-OSM	0
Asialo-[alpha]1-acid glycoprotein	0

Glycobiology 2000-11-01 ;352 Pt 1():37-48.

Cloning, expression and gene organization of a human Neu5Ac alpha 2-3Gal beta 1-3GalNAc alpha 2,6-sialyltransferase: hST6GalNAcIV.

Harduin-Lepers A. et al. PMID:11062056 Refer to: Table 1

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Not Transferred

	JCGG-STR002614 GlyTouCan: G48558GR GlyCosmos Glycans: G48558GR

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO

	JCGG-STR012166 GlyTouCan: G05212BT GlyCosmos Glycans: G05212BT

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR024659 GlyTouCan: G46677TE GlyCosmos Glycans: G46677TE

	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR027464 GlyTouCan: G21856LC GlyCosmos Glycans: G21856LC

	JCGG-STR031354 GlyTouCan: G03277YI GlyCosmos Glycans: G03277YI

	JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR

	JCGG-STR031525 GlyTouCan: G46776WR GlyCosmos Glycans: G46776WR

	JCGG-STR031526 GlyTouCan: G64527IJ GlyCosmos Glycans: G64527IJ

	JCGG-STR031526 GlyTouCan: G64527IJ GlyCosmos Glycans: G64527IJ

	JCGG-STR031557 GlyTouCan: G41722LN GlyCosmos Glycans: G41722LN

table 1
Glycoprotein	Enzyme activity
Asialofetuin	131
Fetuin	100
Asialo-BSM	20
BSM	1
Asialo-[alpha]1-acid glycoprotein	0
Asialo-OSM	0
OSM	0
[alpha]1-acid glycoprotein	0

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Biochem. J. 2000-04-01 ;1474(2):201-11.

Molecular cloning and functional expression of human ST6GalNAc II. Molecular expression in various human cultured cells.

Samyn-Petit B. et al. PMID:10742600

heartkidneyliverskeletal musclesmall intestine

Gene Ontology

Provided by GOA

Function
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
sialyltransferase activity

Process
O-glycan processing
ganglioside biosynthetic process
oligosaccharide metabolic process
protein N-linked glycosylation via asparagine
sialylation

Component
Golgi membrane
integral component of Golgi membrane

This page does not indicate all of the enzymatic reaction, and expression of "ST6GALNAC2".