GGDB:

ST6GALNAC3あるいはN-アセチルガラクトサミニドα-2,6-シアリルトランスフェラーゼ3は、シアリル酸をCMPシアリル酸からフェチュインなどの糖タンパク質上のNeuAcα2→3Galβ1→3GalNAc-Ser/Thr構造に転移する。GM1bガングリオシド、NeuAcα2→3Galβ1→3GalNAcβ1→4Galβ1→4Glc-Cerも、ST6GALNAC3の良い基質となる。ST6GALNAC3はSTYあるいはSIAT7Cとしても知られる。

Keyword:

	CMP-Neu5Ac
JCGG-STR027271 GlyTouCan: G03277YI GlyCosmos Glycans: G03277YI		JCGG-STR014560 GlyTouCan: G45714BQ GlyCosmos Glycans: G45714BQ

	CMP-Neu5Ac
JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE		JCGG-STR026341 GlyTouCan: G01614ZM GlyCosmos Glycans: G01614ZM

Sialyltransferase

GGDB Symbol

ST6GALNAC3 Alias

Designation

GalNAc alpha-2, 6-sialyltransferase III

Organism

Homo sapiens

GeneID

256435

HGNC

ST6GALNAC3 (19343)

mRNA

NM_152996

map

1p31.1

Protein

NP_694541

EC#

CAZy

GT29

GlyCosmos Glycogenes

ST6GALNAC3

OMIM

610133

Disease name

GDGDB

Human Protein Atlas

ENSG00000184005

Mus musculus

mRNA	NM_011372
Protein	NP_035502
MGI	41658

Rattus norvegicus

mRNA	NM_019123
Protein	NP_061996

J. Biochem. 1999-04-01 ;274(17):11958-67.

Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV.

Lee YC. et al. PMID:10207017

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR027271 GlyTouCan: G03277YI GlyCosmos Glycans: G03277YI	CMP-Neu5Ac	JCGG-STR014560 GlyTouCan: G45714BQ GlyCosmos Glycans: G45714BQ

J. Biol. Chem. 1999-11-01 ;9(11):1213-24.

Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens.

Ikehara Y. et al. PMID:10536037 Refer to: Table I.

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE	CMP-Neu5Ac	JCGG-STR026341 GlyTouCan: G01614ZM GlyCosmos Glycans: G01614ZM

Substrate Not Transferred

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO

J. Biol. Chem. 2005-09-01 ;138(3):237-43.

Molecular cloning and expression of human ST6GalNAc III: restricted tissue distribution and substrate specificity.

Tsuchida A. et al. PMID:16169874

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR025535 GlyTouCan: G65562ZE GlyCosmos Glycans: G65562ZE	CMP-Neu5Ac	JCGG-STR026341 GlyTouCan: G01614ZM GlyCosmos Glycans: G01614ZM

J. Biochem. 1996-03-01 ;271(13):7450-9.

Molecular cloning of a developmentally regulated N-acetylgalactosamine alpha2,6-sialyltransferase specific for sialylated glycoconjugates.

Sjoberg ER. et al. PMID:8631773

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Provided by GOA

Function
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
sialyltransferase activity

Process
ganglioside biosynthetic process
glycoprotein metabolic process
glycosphingolipid metabolic process
glycosylceramide metabolic process
oligosaccharide metabolic process
protein N-linked glycosylation via asparagine
sialylation

Component
Golgi membrane
integral component of membrane

ST6GALNAC3

Sialyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Molecular cloning and functional expression of two members of mouse NeuAcalpha2,3Galbeta1,3GalNAc GalNAcalpha2,6-sialyltransferase family, ST6GalNAc III and IV.

DONOR : CMP-Neu5Ac

Substrate Transferred

Cloning and expression of a human gene encoding an N-acetylgalactosamine-alpha2,6-sialyltransferase (ST6GalNAc I): a candidate for synthesis of cancer-associated sialyl-Tn antigens.

DONOR : CMP-Neu5Ac

Substrate Transferred

Substrate Not Transferred

Molecular cloning and expression of human ST6GalNAc III: restricted tissue distribution and substrate specificity.

DONOR : CMP-Neu5Ac

Substrate Transferred

Molecular cloning of a developmentally regulated N-acetylgalactosamine alpha2,6-sialyltransferase specific for sialylated glycoconjugates.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Gene Ontology