GGDB:

ST6GALNAC5, N-acetylgalactosaminide α-2,6-sialyltransferase 5, transfers sialic acid from CMP-sialic acid to the NeuAcα2→3Galβ1→3GalNAc-R structure on glycolipids. ST6GALNAC5 is also called as SIAT7E. ST6GALNAC5 is a GM1b-specific α2,6-sialyltransferase, which synthesizes GD1α and is mainly expressed in the brain.

Keyword:

	CMP-Neu5Ac
JCGG-STR031354 GlyTouCan: G03277YI GlyCosmos Glycans: G03277YI		JCGG-STR031355 GlyTouCan: G45714BQ GlyCosmos Glycans: G45714BQ

Sialyltransferase

GGDB Symbol

ST6GALNAC5 Alias

Designation

GalNAc alpha-2, 6-sialyltransferase V

Organism

Homo sapiens

GeneID

81849

HGNC

ST6GALNAC5 (19342)

mRNA

NM_030965

map

1p31.1

Protein

NP_112227

EC#

CAZy

GlyCosmos Glycogenes

ST6GALNAC5

OMIM

610134

Disease name

GDGDB

Human Protein Atlas

ENSG00000117069

J. Biol. Chem. 1999-10-01 ;274(43):30557-62.

Molecular cloning of brain-specific GD1alpha synthase (ST6GalNAc V) containing CAG/Glutamine repeats.

Okajima T. et al. PMID:10521438 Refer to: TABLE I

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR031354 GlyTouCan: G03277YI GlyCosmos Glycans: G03277YI	CMP-Neu5Ac	JCGG-STR031355 GlyTouCan: G45714BQ GlyCosmos Glycans: G45714BQ

J. Biol. Chem. 1999-12-01 ;463(1-2):92-6.

A novel glycosyltransferase with a polyglutamine repeat; a new candidate for GD1alpha synthase (ST6GalNAc V)(1).

Ikehara Y. et al. PMID:10601645 Refer to: Fig. 2

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR031354 GlyTouCan: G03277YI GlyCosmos Glycans: G03277YI	CMP-Neu5Ac	JCGG-STR031355 GlyTouCan: G45714BQ GlyCosmos Glycans: G45714BQ

J. Biol. Chem. 2003-06-01 ;278(25):22787-94.

Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides.

Tsuchida A. et al. PMID:12668675 Refer to: TABLE I

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR031354 GlyTouCan: G03277YI GlyCosmos Glycans: G03277YI	CMP-Neu5Ac	JCGG-STR031355 GlyTouCan: G45714BQ GlyCosmos Glycans: G45714BQ

	JCGG-STR026949 GlyTouCan: G79536OW GlyCosmos Glycans: G79536OW	CMP-Neu5Ac	JCGG-STR031361 GlyTouCan: G23347CS GlyCosmos Glycans: G23347CS

Substrate Not Transferred

	JCGG-STR031363 GlyTouCan: G01767JJ GlyCosmos Glycans: G01767JJ

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ

	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO

	JCGG-STR031359 GlyTouCan: G50321QR GlyCosmos Glycans: G50321QR

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Provided by GOA

Function
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
sialyltransferase activity

Process
ganglioside biosynthetic process
glycosphingolipid biosynthetic process
oligosaccharide biosynthetic process
oligosaccharide metabolic process
protein N-linked glycosylation via asparagine
sialylation

Component
Golgi membrane
integral component of membrane

ST6GALNAC5

Sialyltransferase

Orthologous Gene

Acceptor Substrates (Reference)

Molecular cloning of brain-specific GD1alpha synthase (ST6GalNAc V) containing CAG/Glutamine repeats.

DONOR : CMP-Neu5Ac

Substrate Transferred

A novel glycosyltransferase with a polyglutamine repeat; a new candidate for GD1alpha synthase (ST6GalNAc V)(1).

DONOR : CMP-Neu5Ac

Substrate Transferred

Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides.

DONOR : CMP-Neu5Ac

Substrate Transferred

Substrate Not Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Gene Ontology