GGDB:

ST8SIA1, ST8 α-N-acetylneuraminide α-2,8-sialyltransferase 1, transfers sialic acid from CMP-sialic acid to the NeuAcα2→3Galβ1→4Glc-Cer (GM3). ST8SIA1 is also called as GD3/GT3 synthase or SIAT8A. ST8SIA1-deficient ES cells do not synthesize b-series gangliosides. Double deficient mice of ST8SIA1 and B4GALNT1 express GM3 as the major ganglioside and exhibited lethal audiogenic seizures.

Keyword: GD3 , GT3 , ganglioside

	CMP-Neu5Ac
JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK		JCGG-STR003473 GlyTouCan: G98544DH GlyCosmos Glycans: G98544DH

	CMP-Neu5Ac
JCGG-STR003473 GlyTouCan: G98544DH GlyCosmos Glycans: G98544DH		JCGG-STR033508 GlyTouCan: G93899SO GlyCosmos Glycans: G93899SO

Sialyltransferase

GGDB Symbol

ST8SIA1 Alias

Designation

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

Organism

Homo sapiens

GeneID

6489

HGNC

ST8SIA1 (10869)

mRNA

NM_003034

map

12p12.1-p11.2

Protein

NP_003025

EC#

2.4.99.8

CAZy

GT29

GlyCosmos Glycogenes

ST8SIA1

OMIM

601123

Disease name

GDGDB

Human Protein Atlas

ENSG00000111728

Mus musculus

mRNA	NM_011374
Protein	NP_035504
KO_mice_database	151
MGI	26647

Rattus norvegicus

mRNA	NM_012813
Protein	NP_036945

J. Biol. Chem. 1994-06-01 ;269(22):15950-6.

Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase).

Sasaki K. et al. PMID:8195250 Refer to: Fig. 5

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK	CMP-Neu5Ac	JCGG-STR003473 GlyTouCan: G98544DH GlyCosmos Glycans: G98544DH

J. Biol. Chem. 1996-02-01 ;271(7):3684-91.

Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme.

Nakayama J. et al. PMID:8631981 Refer to: Fig. 5

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR003473 GlyTouCan: G98544DH GlyCosmos Glycans: G98544DH	CMP-Neu5Ac	JCGG-STR033508 GlyTouCan: G93899SO GlyCosmos Glycans: G93899SO

J. Biol. Chem. 1996-11-01 ;271(46):29366-71.

Molecular cloning and expression of a fifth type of alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and GT3.

Kono M. et al. PMID:8910600 Refer to: TABLE III

DONOR : CMP-Neu5Ac

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK	CMP-Neu5Ac	JCGG-STR003473 GlyTouCan: G98544DH GlyCosmos Glycans: G98544DH

	JCGG-STR005131 GlyTouCan: G40183QN GlyCosmos Glycans: G40183QN	CMP-Neu5Ac	JCGG-STR004466 GlyTouCan: G18625KA GlyCosmos Glycans: G18625KA

	JCGG-STR027108 GlyTouCan: G01767JJ GlyCosmos Glycans: G01767JJ	CMP-Neu5Ac	JCGG-STR009148 GlyTouCan: G70647TI GlyCosmos Glycans: G70647TI

	JCGG-STR024659 GlyTouCan: G46677TE GlyCosmos Glycans: G46677TE	CMP-Neu5Ac	JCGG-STR027119 GlyTouCan: G68110IF GlyCosmos Glycans: G68110IF

	JCGG-STR027271 GlyTouCan: G03277YI GlyCosmos Glycans: G03277YI	CMP-Neu5Ac	JCGG-STR026081 GlyTouCan: G81983KG GlyCosmos Glycans: G81983KG

Substrate Not Transferred

	JCGG-STR003473 GlyTouCan: G98544DH GlyCosmos Glycans: G98544DH

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 1996-02-01 ;271(7):3684-91.

Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme.

Nakayama J. et al. PMID:8631981

brainfetal brainfetal lunglung

Provided by GOA

Function
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
sialyltransferase activity

Process
carbohydrate metabolic process
cellular response to heat
glycosphingolipid biosynthetic process
positive regulation of cell proliferation
protein glycosylation
sialylation

Component
Golgi membrane
integral component of membrane
integral component of Golgi membrane

ST8SIA1

Sialyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase).

DONOR : CMP-Neu5Ac

Substrate Transferred

Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme.

DONOR : CMP-Neu5Ac

Substrate Transferred

Molecular cloning and expression of a fifth type of alpha2,8-sialyltransferase (ST8Sia V). Its substrate specificity is similar to that of SAT-V/III, which synthesize GD1c, GT1a, GQ1b and GT3.

DONOR : CMP-Neu5Ac

Substrate Transferred

Substrate Not Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme.

Gene Ontology