ST8SIA6, ST8 α-N-acetylneuraminide α-2,8-sialyltransferase 6, transfers sialic acid from CMP-sialic acid to the NeuAcα2→3(6)Gal-R or NeuAcα2→6GalNAc-R structure on glycolipids and O-glycans, synthesizing disialic acid by α2,8-linkage. ST8SIA6 is also known as SIAT8F or ST8Sia-VI. ST8SIA6 exhibits high activity toward O-glycans of glycoproteins, such as bovine submaxillary mucin (BSM) but not to N-glycans.
Keyword:
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JCGG-STR013995
GlyTouCan:
G73578JC
GlyCosmos Glycans:
G73578JC
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JCGG-STR032541
GlyTouCan:
G94903EJ
GlyCosmos Glycans:
G94903EJ
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JCGG-STR005020
GlyTouCan:
G91237TK
GlyCosmos Glycans:
G91237TK
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JCGG-STR003473
GlyTouCan:
G98544DH
GlyCosmos Glycans:
G98544DH
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Sialyltransferase
| ST8SIA6 Alias | |
| Designation | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6 |
| Organism | Homo sapiens |
| GeneID | 338596 |
| HGNC | ST8SIA6 (23317) |
| mRNA | NM_001004470 |
| map | 10p12.33 |
| Protein | NP_001004470 |
| EC# | |
| CAZy | |
| GlyCosmos Glycogenes | ST8SIA6 |
| OMIM | 610139 |
| GDGDB | |
| Human Protein Atlas | ENSG00000148488 |
Mus musculus
