ST8SIA6

Last Update:2016-01-29

ST8SIA6あるいはST8 α-N-アセチルノイラミニドα-2,8-シアリルトランスフェラーゼ6は、CMPシアリル酸からシアリル酸を、糖脂質上およびO-グリカンのNeuAcα2→3(6)Gal-RまたはNeuAcα2→6GalNAc-R構造に転移し2,8-結合でジシアル酸を合成する。ST8SIA6はSIAT8FあるいはST8Sia-VIとも知られる。ST8SIA6は牛顎下腺ムチンなどの糖タンパク質のO-グリカンに強い活性を示すがN-グリカンには活性を示さない。

Keyword:

CMP-Neu5Ac
JCGG-STR013995
GlyTouCan: G73578JC
GlyCosmos Glycans: G73578JC
JCGG-STR032541
GlyTouCan: G94903EJ
GlyCosmos Glycans: G94903EJ

CMP-Neu5Ac
JCGG-STR005020
GlyTouCan: G91237TK
GlyCosmos Glycans: G91237TK
JCGG-STR003473
GlyTouCan: G98544DH
GlyCosmos Glycans: G98544DH

Sialyltransferase


GGDB Symbol ST8SIA6    Alias
DesignationST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 6
OrganismHomo sapiens
GeneID 338596
HGNC ST8SIA6 (23317)
mRNA NM_001004470
map10p12.33
Protein NP_001004470
EC#    
CAZy
GlyCosmos Glycogenes ST8SIA6
OMIM 610139
Disease name
GDGDB
Human Protein Atlas ENSG00000148488
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Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "ST8SIA6".