GGDB:

本酵素はUDP-ガラクトースを糖供与体として、ガラクトースをα１-4結合でラクトシルセラミド(Lactosylceramide; LacCer)へ転移する酵素であり、その生成物としてグロボ系糖脂質であるglobotriaosylceramide (Gb3; CD77)を生合成する。Gb3糖脂質はグロボ系糖脂質の生合成経路の起点となる構造である。

Keyword: CD77 , Gb3 , グリコスフィンゴ脂質 , グロボトリオシルセラミド , 糖脂質

	UDP-Gal
JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW		JCGG-STR002182 GlyTouCan: G00059MO GlyCosmos Glycans: G00059MO

Galactosyltransferase

GGDB Symbol

A4GALT Alias

Designation

alpha 1,4-galactosyltransferase

Organism

Homo sapiens

GeneID

53947

HGNC

A4GALT (18149)

mRNA

NM_017436

map

22q11.2-q13.2

Protein

NP_059132

EC#

2.4.1.228

CAZy

GlyCosmos Glycogenes

A4GALT

OMIM

607922

Disease name

GDGDB

Human Protein Atlas

ENSG00000128274

Mus musculus

mRNA	NM_001004150
Protein	NP_001004150
KO_mice_database	150
MGI	118685

Rattus norvegicus

mRNA	NM_022240
Protein	NP_071576

Drosophila melanogaster

mRNA	NM_134893
Protein	NP_608737

J. Biol. Chem. 2000-06-01 ;275(22):16723-9.

Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype.

Steffensen R. et al. PMID:10747952

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW	UDP-Gal	JCGG-STR002182 GlyTouCan: G00059MO GlyCosmos Glycans: G00059MO

Int. J. Cancer 1995-04-01 ;61(2):261-7.

Differential regulation of glycosphingolipid biosynthesis in phenotypically distinct Burkitt's lymphoma cell lines.

Taga S. et al. PMID:7705957

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 2000-06-01 ;275(22):16723-9.

Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype.

Steffensen R. et al. PMID:10747952

heartkidney

Provided by GOA

Function
galactosyltransferase activity
lactosylceramide 4-alpha-galactosyltransferase activity
toxic substance binding

Process
globoside biosynthetic process
glycosphingolipid biosynthetic process
plasma membrane organization
protein glycosylation

Component
extracellular exosome
integral component of Golgi membrane
membrane

A4GALT

Galactosyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Drosophila melanogaster

Acceptor Substrates (Reference)

Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype.

DONOR : UDP-Gal

Substrate Transferred

Differential regulation of glycosphingolipid biosynthesis in phenotypically distinct Burkitt's lymphoma cell lines.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Cloning and expression of the histo-blood group Pk UDP-galactose: Ga1beta-4G1cbeta1-cer alpha1, 4-galactosyltransferase. Molecular genetic basis of the p phenotype.

Gene Ontology