B3GALT1

Last Update:2017-03-27

β3GalT1(B3GALT1)は1型糖鎖抗原の合成活性を有している。B3GALT1遺伝子は脳に最も発現している。

Keyword: 1型糖鎖抗原

	UDP-Gal
JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO		JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

Galactosyltransferase

GGDB Symbol

B3GALT1 Alias

Designation

beta 1,3-galactosyltransferase 1

Organism

Homo sapiens

GeneID

HGNC

B3GALT1 (916)

mRNA

map

2q24.3

Protein

EC#

CAZy

GT31

GlyCosmos Glycogenes

B3GALT1

OMIM

603093

Disease name

GDGDB

Human Protein Atlas

ENSG00000172318

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Orthologous Gene

Mus musculus

mRNA	NM_020283
Protein	NP_064679
MGI	43754

Rattus norvegicus

mRNA	XM_345362
Protein	XP_345363

Arabidopsis thaliana

mRNA	NM_102445
Protein	NP_174003

Acceptor Substrates (Reference)

Biochim. Biophys. Acta 1999-12-01 ;1473(1):35-53.

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

Amado M. et al. PMID:10580128

J. Biol. Chem. 1998-01-01 ;273(1):433-40.

Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains.

Kolbinger F. et al. PMID:9417100 Refer to: TABLE I

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO	UDP-Gal	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE	UDP-Gal	JCGG-STR004799 GlyTouCan: G95894VW GlyCosmos Glycans: G95894VW

Substrate Not Transferred

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

Biochim. Biophys. Acta 1998-05-01 ;273(21):12770-8.

A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.

Amado M. et al. PMID:9582303 Refer to: TABLE III

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR027022 GlyTouCan: G06239NA GlyCosmos Glycans: G06239NA	UDP-Gal	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO

	JCGG-STR031569 GlyTouCan: G71142DF GlyCosmos Glycans: G71142DF	UDP-Gal	JCGG-STR025739 GlyTouCan: G31761VE GlyCosmos Glycans: G31761VE

	JCGG-STR006200 GlyTouCan: G70874WW GlyCosmos Glycans: G70874WW	UDP-Gal	JCGG-STR012342 GlyTouCan: G86143FV GlyCosmos Glycans: G86143FV

Substrate Not Transferred

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

	JCGG-STR002182 GlyTouCan: G00059MO GlyCosmos Glycans: G00059MO

	JCGG-STR026907 GlyTouCan: G00061MO GlyCosmos Glycans: G00061MO

	JCGG-STR003580 GlyTouCan: G90562PB GlyCosmos Glycans: G90562PB

	JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT

	JCGG-STR002614 GlyTouCan: G48558GR GlyCosmos Glycans: G48558GR

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Biochim. Biophys. Acta 1998-05-01 ;273(21):12770-8.

A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.

Amado M. et al. PMID:9582303

brain

Gene Ontology

Provided by GOA

Function
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

Process
oligosaccharide biosynthetic process
protein glycosylation

Component
Golgi membrane
integral component of membrane

This page does not indicate all of the enzymatic reaction, and expression of "B3GALT1".