B3GALT2

Last Update:2017-03-27

β3GalT2 (B3GALT2) has a synthetic activity for the Type 1 carbohydrate antigen. The B3GALT2 gene is expressed most in the brain.

Keyword: Type 1 carbohydrate antigen

	UDP-Gal
JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO		JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

Galactosyltransferase

GGDB Symbol

B3GALT2 Alias

Designation

beta 1,3-galactosyltransferase 2

Organism

Homo sapiens

GeneID

HGNC

B3GALT2 (917)

mRNA

map

1q31

Protein

EC#

CAZy

GT31

GlyCosmos Glycogenes

B3GALT2

OMIM

603018

Disease name

GDGDB

Human Protein Atlas

ENSG00000162630

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Orthologous Gene

Mus musculus

mRNA	NM_020025
Protein	NP_064409
MGI	43812

Acceptor Substrates (Reference)

Biochim. Biophys. Acta 1999-12-01 ;1473(1):35-53.

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

Amado M. et al. PMID:10580128

J. Biol. Chem. 1998-01-01 ;273(1):433-40.

Cloning of a human UDP-galactose:2-acetamido-2-deoxy-D-glucose 3beta-galactosyltransferase catalyzing the formation of type 1 chains.

Kolbinger F. et al. PMID:9417100 Refer to: TABLE I

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO	UDP-Gal	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE	UDP-Gal	JCGG-STR004799 GlyTouCan: G95894VW GlyCosmos Glycans: G95894VW

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW	UDP-Gal	JCGG-STR028960 GlyTouCan: G45796AX GlyCosmos Glycans: G45796AX

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	UDP-Gal	JCGG-STR031570 GlyTouCan: G35116BF GlyCosmos Glycans: G35116BF

Substrate Not Transferred

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

J. Biol. Chem. 1998-05-01 ;273(21):12770-8.

A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.

Amado M. et al. PMID:9582303 Refer to: TABLE III

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR027022 GlyTouCan: G06239NA GlyCosmos Glycans: G06239NA	UDP-Gal	JCGG-STR002827 GlyTouCan: G00049MO GlyCosmos Glycans: G00049MO

	JCGG-STR006200 GlyTouCan: G70874WW GlyCosmos Glycans: G70874WW	UDP-Gal	JCGG-STR012342 GlyTouCan: G86143FV GlyCosmos Glycans: G86143FV

	JCGG-STR031569 GlyTouCan: G71142DF GlyCosmos Glycans: G71142DF	UDP-Gal	JCGG-STR025739 GlyTouCan: G31761VE GlyCosmos Glycans: G31761VE

Substrate Not Transferred

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

	JCGG-STR002182 GlyTouCan: G00059MO GlyCosmos Glycans: G00059MO

	JCGG-STR026907 GlyTouCan: G00061MO GlyCosmos Glycans: G00061MO

	JCGG-STR003580 GlyTouCan: G90562PB GlyCosmos Glycans: G90562PB

	JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT

	JCGG-STR002614 GlyTouCan: G48558GR GlyCosmos Glycans: G48558GR

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

J. Biol. Chem. 1998-05-01 ;273(21):12770-8.

A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.

Amado M. et al. PMID:9582303

brainheart

Gene Ontology

Provided by GOA

Function
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity

Process
oligosaccharide biosynthetic process
protein glycosylation

Component
Golgi membrane
integral component of membrane

This page does not indicate all of the enzymatic reaction, and expression of "B3GALT2".