B3GALT4

Last Update:2017-03-27

B3GALT4 (β3GalT4) is a human counterpart of the rat GD1b/GM1/GA1 synthase cloned by Miyazaki et al.

Keyword: GA1 , GD1b , GM1 , ganglioside , glycolipid

	UDP-Gal
JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT		JCGG-STR002614 GlyTouCan: G48558GR GlyCosmos Glycans: G48558GR

	UDP-Gal
JCGG-STR031356 GlyTouCan: G02657AK GlyCosmos Glycans: G02657AK		JCGG-STR024670 GlyTouCan: G37184KW GlyCosmos Glycans: G37184KW

	UDP-Gal
JCGG-STR003580 GlyTouCan: G90562PB GlyCosmos Glycans: G90562PB		JCGG-STR027464 GlyTouCan: G21856LC GlyCosmos Glycans: G21856LC

Galactosyltransferase

GGDB Symbol

B3GALT4 Alias

Designation

beta 1,3-galactosyltransferase 4

Organism

Homo sapiens

GeneID

HGNC

B3GALT4 (919)

mRNA

map

6p21.3

Protein

EC#

2.4.1.62

CAZy

GT31

GlyCosmos Glycogenes

B3GALT4

OMIM

603095

Disease name

GDGDB

Human Protein Atlas

ENSG00000235863

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Orthologous Gene

Mus musculus

mRNA	NM_019420
Protein	NP_062293
MGI	46752

Rattus norvegicus

mRNA	NM_133553
Protein	NP_598237

Acceptor Substrates (Reference)

J. Biol. Chem. 1999-12-01 ;1473(1):35-53.

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

Amado M. et al. PMID:10580128

J. Biol. Chem. 1997-10-01 ;272(40):24794-9.

Expression cloning of rat cDNA encoding UDP-galactose:GD2 beta1,3-galactosyltransferase that determines the expression of GD1b/GM1/GA1.

Miyazaki H. et al. PMID:9312075 Refer to: FIG. 6.

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT	UDP-Gal	JCGG-STR002614 GlyTouCan: G48558GR GlyCosmos Glycans: G48558GR

	JCGG-STR031356 GlyTouCan: G02657AK GlyCosmos Glycans: G02657AK	UDP-Gal	JCGG-STR024670 GlyTouCan: G37184KW GlyCosmos Glycans: G37184KW

	JCGG-STR003580 GlyTouCan: G90562PB GlyCosmos Glycans: G90562PB	UDP-Gal	JCGG-STR027464 GlyTouCan: G21856LC GlyCosmos Glycans: G21856LC

Substrate Not Transferred

	JCGG-STR031569 GlyTouCan: G71142DF GlyCosmos Glycans: G71142DF

	JCGG-STR005020 GlyTouCan: G91237TK GlyCosmos Glycans: G91237TK

	JCGG-STR024670 GlyTouCan: G37184KW GlyCosmos Glycans: G37184KW

	JCGG-STR031351 GlyTouCan: G40183QN GlyCosmos Glycans: G40183QN

Biochim. Biophys. Acta 1998-05-01 ;273(21):12770-8.

A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.

Amado M. et al. PMID:9582303 Refer to: TABLE IV

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT	UDP-Gal	JCGG-STR002614 GlyTouCan: G48558GR GlyCosmos Glycans: G48558GR

	JCGG-STR003580 GlyTouCan: G90562PB GlyCosmos Glycans: G90562PB	UDP-Gal	JCGG-STR027464 GlyTouCan: G21856LC GlyCosmos Glycans: G21856LC

Substrate Not Transferred

	JCGG-STR031569 GlyTouCan: G71142DF GlyCosmos Glycans: G71142DF

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

	JCGG-STR002182 GlyTouCan: G00059MO GlyCosmos Glycans: G00059MO

	JCGG-STR026907 GlyTouCan: G00061MO GlyCosmos Glycans: G00061MO

	JCGG-STR002614 GlyTouCan: G48558GR GlyCosmos Glycans: G48558GR

	JCGG-STR027022 GlyTouCan: G06239NA GlyCosmos Glycans: G06239NA

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ

	JCGG-STR006200 GlyTouCan: G70874WW GlyCosmos Glycans: G70874WW

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

J. Biol. Chem. 1997-10-01 ;272(40):24794-9.

Expression cloning of rat cDNA encoding UDP-galactose:GD2 beta1,3-galactosyltransferase that determines the expression of GD1b/GM1/GA1.

Miyazaki H. et al. PMID:9312075

Biochim. Biophys. Acta 1998-05-01 ;273(21):12770-8.

A family of human beta3-galactosyltransferases. Characterization of four members of a UDP-galactose:beta-N-acetyl-glucosamine/beta-nacetyl-galactosamine beta-1,3-galactosyltransferase family.

Amado M. et al. PMID:9582303

cerebellumcerebrumkidneyliverspleentestisthymus

Gene Ontology

Provided by GOA

Function
UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
ganglioside galactosyltransferase activity

Process
protein glycosylation

Component
Golgi membrane
integral component of membrane

This page does not indicate all of the enzymatic reaction, and expression of "B3GALT4".