GGDB:

B3GALT6 encodes beta-1,3-galactosyltransferase 6. This enzyme uses Galβ- at the non-reducing end as an acceptor substrate & transfers Gal with a β1,3 linkage to synthesize Galβ1,3Galβ-. This structure is found in the linkage structure (GlcAβ1-3Galβ1-3Galβ1-4Xyl-O-Ser/Thr) between glycosaminoglycans such as heparan sulfate and chondroitin sulfate and proteoglycan core proteins.

Keyword: Chondroitin sulfate , Heparan sulfate , glycosaminoglycan

	UDP-Gal
JCGG-STR018505 GlyTouCan: G78098IA GlyCosmos Glycans: G78098IA		JCGG-STR028206 GlyTouCan: G87877ES GlyCosmos Glycans: G87877ES

Galactosyltransferase

GGDB Symbol

B3GALT6 Alias

Designation

beta 1,3-galactosyltransferase 6

Organism

Homo sapiens

GeneID

126792

HGNC

B3GALT6 (17978)

mRNA

NM_080605

map

1p36.33

Protein

NP_542172

EC#

2.4.1.134

CAZy

GT31

GlyCosmos Glycogenes

B3GALT6

OMIM

615291

Disease name

GDGDB

Human Protein Atlas

ENSG00000176022

Mus musculus

mRNA	NM_080445
Protein	NP_536693
MGI	77575

Rattus norvegicus

mRNA	NM233721
Protein	XP_233721

Caenorhabditis elegans

mRNA	NM_061993
Protein	NP_494394

Drosophila melanogaster

mRNA	NM_136555
Protein	NP_610399

J. Biol. Chem. 2001-12-01 ;276(51):48189-95.

Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).

Bai X. et al. PMID:11551958 Refer to: Table 1.

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR018505 GlyTouCan: G78098IA GlyCosmos Glycans: G78098IA	UDP-Gal	JCGG-STR028206 GlyTouCan: G87877ES GlyCosmos Glycans: G87877ES

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE	UDP-Gal	JCGG-STR004799 GlyTouCan: G95894VW GlyCosmos Glycans: G95894VW

	JCGG-STR025711 GlyTouCan: G00031MO GlyCosmos Glycans: G00031MO	UDP-Gal	JCGG-STR026327 GlyTouCan: G70693FX GlyCosmos Glycans: G70693FX

	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO	UDP-Gal	JCGG-STR031570 GlyTouCan: G35116BF GlyCosmos Glycans: G35116BF

	JCGG-STR004799 GlyTouCan: G95894VW GlyCosmos Glycans: G95894VW	UDP-Gal	JCGG-STR014157 GlyTouCan: G59103JC GlyCosmos Glycans: G59103JC

Substrate Not Transferred

	JCGG-STR031571 GlyTouCan: G16579HJ GlyCosmos Glycans: G16579HJ

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR021541 GlyTouCan: G00056MO GlyCosmos Glycans: G00056MO

	JCGG-STR004754 GlyTouCan: G33476GF GlyCosmos Glycans: G33476GF

	JCGG-STR007097 GlyTouCan: G51379UR GlyCosmos Glycans: G51379UR

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

J. Biol. Chem. 2001-12-01 ;276(51):48189-95.

Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).

Bai X. et al. PMID:11551958

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B3GALT6

Galactosyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Acceptor Substrates (Reference)

Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).

DONOR : UDP-Gal

Substrate Transferred

Substrate Not Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Biosynthesis of the linkage region of glycosaminoglycans: cloning and activity of galactosyltransferase II, the sixth member of the beta 1,3-galactosyltransferase family (beta 3GalT6).

Gene Ontology