C1GALT1 encodes a core 1 synthase； glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1. This enzyme uses the non-reducing terminal GalNAc alpha- as an acceptor substrate and transfers Gal via beta1,3 linkage to synthesize Gal beta1,3GalNAc alpha-. This structure is known as the core 1 structure of O-linked glycans or T antigen/TF antigen. In mammals, cosmc, a core1 GalT1-specific chaperone molecule, is required for the normal folding of Core1 GalT protein.
Keyword:
O-linked glycans
, T-antigen
, TF-antigen
, core 1
, cosmc
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JCGG-STR025718
GlyTouCan:
G57321FI
GlyCosmos Glycans:
G57321FI
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JCGG-STR025711
GlyTouCan:
G00031MO
GlyCosmos Glycans:
G00031MO
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Galactosyltransferase
| C1GALT1 Alias | |
| Designation | core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1 |
| Organism | Homo sapiens |
| GeneID | 56913 |
| HGNC | C1GALT1 (24337) |
| mRNA | NM_020156 |
| map | 7p14-p13 |
| Protein | NP_064541 |
| EC# | 2.4.1.122 |
| CAZy | GT31 |
| GlyCosmos Glycogenes | C1GALT1 |
| OMIM | 610555 |
| GDGDB | |
| Human Protein Atlas | ENSG00000106392 |
Mus musculus
Rattus norvegicus
Caenorhabditis elegans
Drosophila melanogaster
