GGDB:

C1GALT1C1はC1GALT1 specific chaperone 1をコードする。本タンパク質はcosmc (core 1 β3-Gal-T-specific molecular chaperone)とも呼ばれる。cosmcは糖転移酵素活性は有さず、小胞体に局在し、core1 GalTタンパク質の正常な分子フォールディングのために機能している。

Keyword: O-結合型糖鎖 , TF抗原 , T抗原 , cosmc , コア1 , シャペロン

Glycosyltransferase chaperone

GGDB Symbol

C1GALT1C1 Alias

Designation

core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 2

Organism

Homo sapiens

GeneID

29071

HGNC

C1GALT1C1 (24338)

mRNA

NM_152692

map

Xq24

Protein

NP_689905

EC#

2.4.1.122

CAZy

GlyCosmos Glycogenes

C1GALT1C1

OMIM

300611

Disease name

GDGDB

Human Protein Atlas

ENSG00000171155

Mus musculus

mRNA	NM_021550
Protein	NP_067525
MGI	50223

Rattus norvegicus

mRNA	NM_001030033
Protein	NP_001025204

Proc Natl Acad Sci U S A 2002-12-01 ;277(49):47724-31.

Molecular cloning and characterization of a novel UDP-Gal:GalNAc(alpha) peptide beta 1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan.

Kudo T. et al. PMID:12361956

Proc Natl Acad Sci U S A 2002-12-01 ;99(26):16613-8.

A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase.

Ju T. et al. PMID:12464682

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Proc Natl Acad Sci U S A 2002-12-01 ;277(49):47724-31.

Molecular cloning and characterization of a novel UDP-Gal:GalNAc(alpha) peptide beta 1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan.

Kudo T. et al. PMID:12361956

bone marrowbraincerebellumcerebral cortexcolonheartkidneyliverlungmammary glandovarypancreasperipheral blood leukocyteplacentaprostatesalivary glandskeletal musclesmall intestinespinal cordspleenstomachtestisthymusthyroid glandtracheauterus

Provided by GOA

Function
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity
protein binding

Process
O-glycan processing
O-glycan processing
O-glycan processing, core 1
platelet activation
platelet morphogenesis
protein O-linked glycosylation

Component
Golgi membrane
extracellular exosome
integral component of membrane

C1GALT1C1

Glycosyltransferase chaperone

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Molecular cloning and characterization of a novel UDP-Gal:GalNAc(alpha) peptide beta 1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan.

A unique molecular chaperone Cosmc required for activity of the mammalian core 1 beta 3-galactosyltransferase.

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Molecular cloning and characterization of a novel UDP-Gal:GalNAc(alpha) peptide beta 1,3-galactosyltransferase (C1Gal-T2), an enzyme synthesizing a core 1 structure of O-glycan.

Gene Ontology