GGDB:

本遺伝子は1型糖鎖抗原(Galb1-4GlcNAc-R)の合成に関与する酵素をコードしている。本酵素は糖供与体UDP-GalからGalをb1-4結合で糖受容体基質(GlcNAc-R)に転移する活性を有する。

Keyword: 2型糖鎖抗原

	UDP-Gal
JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO		JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	UDP-Gal
JCGG-STR002004 GlyTouCan: G76294XX GlyCosmos Glycans: G76294XX		JCGG-STR032575 GlyTouCan: G80524SB GlyCosmos Glycans: G80524SB

	UDP-Gal
JCGG-STR026378 GlyTouCan: G71817IG GlyCosmos Glycans: G71817IG		JCGG-STR032576 GlyTouCan: G81756OO GlyCosmos Glycans: G81756OO

Galactosyltransferase

GGDB Symbol

B4GALT2 Alias

Designation

beta 1,4-galactosyltransferase 2

Organism

Homo sapiens

GeneID

8704

HGNC

B4GALT2 (925)

mRNA

NM_003780

map

1p34-p33

Protein

NP_003771

EC#

2.4.1.38

CAZy

GT7

GlyCosmos Glycogenes

B4GALT2

OMIM

604013

Disease name

GDGDB

Human Protein Atlas

ENSG00000117411

Mus musculus

mRNA	NM_017377
Protein	NP_059073
KO_mice_database	12
MGI	46515

Rattus norvegicus

mRNA	XM_242992
Protein	XP_242992

Drosophila melanogaster

mRNA	NM_137102
Protein	NP_610946

Glycobiology 1999-12-01 ;1473(1):35-53.

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

Amado M. et al. PMID:10580128

Nat. Methods 2003-03-01 ;278(11):9150-8.

Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.

Seko A. et al. PMID:12511560

Proc. Natl. Acad. Sci. U.S.A. 2007-07-01 ;4(7):577-82.

Strategy for the fine characterization of glycosyltransferase specificity using isotopomer assembly.

Ito H. et al. PMID:17529980

Nat. Methods 1997-12-01 ;272(51):31979-91.

A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3.

Almeida R. et al. PMID:9405390 Refer to: TABLE I

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR023532 GlyTouCan: G14651SS GlyCosmos Glycans: G14651SS	UDP-Gal	JCGG-STR026086 GlyTouCan: G93379VC GlyCosmos Glycans: G93379VC

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO	UDP-Gal	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

Substrate Not Transferred

	JCGG-STR004754 GlyTouCan: G33476GF GlyCosmos Glycans: G33476GF

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO

	JCGG-STR008690 GlyTouCan: G68544GH GlyCosmos Glycans: G68544GH

	JCGG-STR008690 GlyTouCan: G68544GH GlyCosmos Glycans: G68544GH

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO

	JCGG-STR008362 GlyTouCan: G61418DU GlyCosmos Glycans: G61418DU

	JCGG-STR008362 GlyTouCan: G61418DU GlyCosmos Glycans: G61418DU

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

Glycobiology 1998-01-01 ;95(2):472-7.

Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase.

Sato T. et al. PMID:9435216 Refer to: Table 2.

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR002004 GlyTouCan: G76294XX GlyCosmos Glycans: G76294XX	UDP-Gal	JCGG-STR032575 GlyTouCan: G80524SB GlyCosmos Glycans: G80524SB

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO	UDP-Gal	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	JCGG-STR027385 GlyTouCan: G87229LF GlyCosmos Glycans: G87229LF	UDP-Gal	JCGG-STR032577 GlyTouCan: G50361AJ GlyCosmos Glycans: G50361AJ

	JCGG-STR026378 GlyTouCan: G71817IG GlyCosmos Glycans: G71817IG	UDP-Gal	JCGG-STR032576 GlyTouCan: G81756OO GlyCosmos Glycans: G81756OO

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Nat. Methods 2003-03-01 ;278(11):9150-8.

Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.

Seko A. et al. PMID:12511560

Nat. Methods 1997-12-01 ;272(51):31979-91.

A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3.

Almeida R. et al. PMID:9405390

Glycobiology 1998-01-01 ;95(2):472-7.

Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase.

Sato T. et al. PMID:9435216

Proc. Natl. Acad. Sci. U.S.A. 1998-05-01 ;8(5):517-26.

The expanding beta 4-galactosyltransferase gene family: messages from the databanks.

Lo NW. et al. PMID:9597550

fetal brainheartintestineovarypancreasprostateskeletal muscletestis

B4GALT2

Galactosyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Drosophila melanogaster

Acceptor Substrates (Reference)

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.

Strategy for the fine characterization of glycosyltransferase specificity using isotopomer assembly.

A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3.

DONOR : UDP-Gal

Substrate Transferred

Substrate Not Transferred

Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase.

DONOR : UDP-Gal

Substrate Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.

A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3.

Molecular cloning of a human cDNA encoding beta-1,4-galactosyltransferase with 37% identity to mammalian UDP-Gal:GlcNAc beta-1,4-galactosyltransferase.

The expanding beta 4-galactosyltransferase gene family: messages from the databanks.

Gene Ontology