GGDB:

本遺伝子は2型糖鎖構造(Galb1-4GlcNAc-R)の合成に関与するb1,4-ガラクト−ス転移酵素3をコードしている。本酵素は糖供与体UDP-GalからGalをb1-4結合で糖受容体基質の非還元末端に存在するGlcNAcに転移する活性を有する。アガラクト体N-Glycan（4本鎖）のオリゴ糖基質に対しては、GlcNAcb1-4Man鎖(MGAT4が生合成)が一番特異性（反応性）が高く、まずこの位置へガラクトースを転移した後、次にGlcNAcb1-2Man鎖(MGAT1が生合成)、GlcNAcb1-4Man鎖(MGAT2が生合成)の順にガラクトースを転移させる傾向がある。また糖脂質の2型糖鎖構造（Galb1-4GlaNAcb1-3Galb1-4Glca-Cer）の生合成にも関与する。

Keyword: 2型糖鎖抗原

	UDP-Gal
JCGG-STR001606 GlyTouCan: G55302WQ GlyCosmos Glycans: G55302WQ		JCGG-STR033344 GlyTouCan: G62048AU GlyCosmos Glycans: G62048AU

	UDP-Gal
JCGG-STR027022 GlyTouCan: G06239NA GlyCosmos Glycans: G06239NA		JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ

	UDP-Gal
JCGG-STR027022 GlyTouCan: G06239NA GlyCosmos Glycans: G06239NA		JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ

Galactosyltransferase

GGDB Symbol

B4GALT3 Alias

Designation

beta 1,4-galactosyltransferase 3

Organism

Homo sapiens

GeneID

8703

HGNC

B4GALT3 (926)

mRNA

NM_003779

map

1q21-q23

Protein

NP_003770

EC#

2.4.1.38

CAZy

GT7

GlyCosmos Glycogenes

B4GALT3

OMIM

604014

Disease name

GDGDB

Human Protein Atlas

ENSG00000158850

Mus musculus

mRNA	NM_020579
Protein	NP_065604
MGI	49271

Rattus norvegicus

mRNA	BC061812
Protein	AAH61812

Caenorhabditis elegans

mRNA	NM_058471
Protein	NP_490872

Drosophila melanogaster

mRNA	NM_143400
Protein	NP_651657

Biochim. Biophys. Acta 1999-12-01 ;1473(1):35-53.

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

Amado M. et al. PMID:10580128

Biochim. Biophys. Acta 2003-03-01 ;278(11):9150-8.

Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.

Seko A. et al. PMID:12511560

Biochim. Biophys. Acta 2007-07-01 ;4(7):577-82.

Strategy for the fine characterization of glycosyltransferase specificity using isotopomer assembly.

Ito H. et al. PMID:17529980

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR001606 GlyTouCan: G55302WQ GlyCosmos Glycans: G55302WQ	UDP-Gal	JCGG-STR033344 GlyTouCan: G62048AU GlyCosmos Glycans: G62048AU

Biochim. Biophys. Acta 1997-12-01 ;272(51):31979-91.

A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3.

Almeida R. et al. PMID:9405390 Refer to: Table II

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO	UDP-Gal	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	JCGG-STR023532 GlyTouCan: G14651SS GlyCosmos Glycans: G14651SS	UDP-Gal	JCGG-STR026086 GlyTouCan: G93379VC GlyCosmos Glycans: G93379VC

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO	UDP-Gal	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO	UDP-Gal	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	JCGG-STR027022 GlyTouCan: G06239NA GlyCosmos Glycans: G06239NA	UDP-Gal	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO	UDP-Gal	JCGG-STR013782 GlyTouCan: G00055MO GlyCosmos Glycans: G00055MO

	JCGG-STR004754 GlyTouCan: G33476GF GlyCosmos Glycans: G33476GF	UDP-Gal	JCGG-STR010522 GlyTouCan: G06580KR GlyCosmos Glycans: G06580KR

	JCGG-STR006200 GlyTouCan: G70874WW GlyCosmos Glycans: G70874WW	UDP-Gal	JCGG-STR026436 GlyTouCan: G84034JH GlyCosmos Glycans: G84034JH

	JCGG-STR031569 GlyTouCan: G71142DF GlyCosmos Glycans: G71142DF	UDP-Gal	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

Substrate Not Transferred

	JCGG-STR008276 GlyTouCan: G49108TO GlyCosmos Glycans: G49108TO

	JCGG-STR008690 GlyTouCan: G68544GH GlyCosmos Glycans: G68544GH

	JCGG-STR008690 GlyTouCan: G68544GH GlyCosmos Glycans: G68544GH

	JCGG-STR008362 GlyTouCan: G61418DU GlyCosmos Glycans: G61418DU

	JCGG-STR008362 GlyTouCan: G61418DU GlyCosmos Glycans: G61418DU

	JCGG-STR025718 GlyTouCan: G57321FI GlyCosmos Glycans: G57321FI

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR031555 GlyTouCan: G65889KE GlyCosmos Glycans: G65889KE

	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

	JCGG-STR002182 GlyTouCan: G00059MO GlyCosmos Glycans: G00059MO

	JCGG-STR026907 GlyTouCan: G00061MO GlyCosmos Glycans: G00061MO

	JCGG-STR003580 GlyTouCan: G90562PB GlyCosmos Glycans: G90562PB

	JCGG-STR004355 GlyTouCan: G79389NT GlyCosmos Glycans: G79389NT

	JCGG-STR002614 GlyTouCan: G48558GR GlyCosmos Glycans: G48558GR

	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ

Biochim. Biophys. Acta 1998-11-01 ;273(45):29331-40.

Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis.

Schwientek T. et al. PMID:9792633 Refer to: Table II

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR027022 GlyTouCan: G06239NA GlyCosmos Glycans: G06239NA	UDP-Gal	JCGG-STR026439 GlyTouCan: G58896AZ GlyCosmos Glycans: G58896AZ

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Biochim. Biophys. Acta 2003-03-01 ;278(11):9150-8.

Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.

Seko A. et al. PMID:12511560

Biochim. Biophys. Acta 1997-12-01 ;272(51):31979-91.

A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3.

Almeida R. et al. PMID:9405390

J. Biol. Chem. 1998-05-01 ;8(5):517-26.

The expanding beta 4-galactosyltransferase gene family: messages from the databanks.

Lo NW. et al. PMID:9597550

braincolonfetal brainfetal kidneyfetal liverfetal lungheartintestineliverlungovarypancreasperipheral blood leukocyteplacentaprostateskeletal musclespleentestisthymus

B4GALT3

Galactosyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Caenorhabditis elegans

Drosophila melanogaster

Acceptor Substrates (Reference)

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.

Strategy for the fine characterization of glycosyltransferase specificity using isotopomer assembly.

DONOR : UDP-Gal

Substrate Transferred

A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3.

DONOR : UDP-Gal

Substrate Transferred

Substrate Not Transferred

Cloning of a novel member of the UDP-galactose:beta-N-acetylglucosamine beta1,4-galactosyltransferase family, beta4Gal-T4, involved in glycosphingolipid biosynthesis.

DONOR : UDP-Gal

Substrate Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.

A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3.

The expanding beta 4-galactosyltransferase gene family: messages from the databanks.

Gene Ontology