B4GALT4 |
Last Update:2017-03-27 |
This gene encodes beta-1,4-galactosyltransferase 4 that is involved in the synthesis of the Type 2 carbohydrate antigen (Galb1-4GlcNAc-R). This enzyme has the activity that transfers a Gal from the donor UDP-Gal to the GlcNAc of the non-reducing terminal of the acceptor by the b1-4 bond. In particular, it is involved in the synthesis of the carbohydrate chains of the glycolipids (nLc4Cer; paragloboside or nLc6Cer etc.). It also synthesizes the keratan sulfate proteoglycan by the transfer of a galactose to the GlcNAc 6-O-sulfate structure such as SO3 -6GlcNAc b1-3Galb1-4 (SO3-6)GlcNAc. The GlcNAcb1-2Man (synthesized by MGAT1) has the highest specificity (reactivity) to the agalacto type N-linked oligosaccharides (4-chain). First, it transfers a galactose to this position, after that it tends to transfer a galactose to GlcNAcb1-4Man (synthesized by MGAT4) or to GlcNAcb1-4Man (synthesized by MGAT2), with almost equal probability. However, there are reports that it does not show activity on glycoproteins. It is involved in the biosynthesis of the type 2 glycolipids (Galb1-4GlaNAcb1-3Galb1-4Glca-Cer or Galb1-4GlaNAcb1-3Galb1-4GlaNAcb1-3Galb1-4Glca-Cer). There are also reports that it is also involved in the synthesis of the lactosamine extended on the core 2 type O-glycan.
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JCGG-STR008427
GlyTouCan:
G17441VE
GlyCosmos Glycans:
G17441VE
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JCGG-STR000935
GlyTouCan:
G13157WZ
GlyCosmos Glycans:
G13157WZ
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JCGG-STR001606
GlyTouCan:
G55302WQ
GlyCosmos Glycans:
G55302WQ
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JCGG-STR031397
GlyTouCan:
G08863NS
GlyCosmos Glycans:
G08863NS
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JCGG-STR027022
GlyTouCan:
G06239NA
GlyCosmos Glycans:
G06239NA
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JCGG-STR026439
GlyTouCan:
G58896AZ
GlyCosmos Glycans:
G58896AZ
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JCGG-STR033540
GlyTouCan:
G21828TB
GlyCosmos Glycans:
G21828TB
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JCGG-STR033541
GlyTouCan:
G24366HE
GlyCosmos Glycans:
G24366HE
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B4GALT4 Alias | |
Designation | beta 1,4-galactosyltransferase 4 |
Organism | Homo sapiens |
GeneID | 8702 |
HGNC | B4GALT4 (927) |
mRNA | NM_003778 |
map | 3q13.3 |
Protein | NP_003769 |
EC# | 2.4.1.90 |
CAZy | GT7 |
GlyCosmos Glycogenes | B4GALT4 |
OMIM | 604015 |
GDGDB | |
Human Protein Atlas | ENSG00000121578 |
data available from v22.proteinatlas.org