GGDB:

UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6 (B4GALT6) transfers galactose to glucosylceramide. B4GALT6 is also known as β4GalT-IV and β-1,4-galactosyltransferase 6. B4GALT family is consist of 7 β-1,4-galactosyltransferases, which show different substrate specificity and expression patterns. B4GALT6 is considered as a lactosylceramide (LacCer) synthase important for glycolipid biosynthesis. (However, LacCer synthase activity was decreased in B4GALT5-deficient mice, but the activity was not confirmed in vitro.)

Keyword:

	UDP-Gal
JCGG-STR031569 GlyTouCan: G71142DF GlyCosmos Glycans: G71142DF		JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

Galactosyltransferase

GGDB Symbol

B4GALT6 Alias

Designation

beta 1,4-galactosyltransferase 6

Organism

Homo sapiens

GeneID

9331

HGNC

B4GALT6 (929)

mRNA

NM_004775

map

18q11

Protein

NP_004766

EC#

2.4.1.22

CAZy

GT7

GlyCosmos Glycogenes

B4GALT6

OMIM

604017

Disease name

GDGDB

Human Protein Atlas

ENSG00000118276

Mus musculus

mRNA	NM_019737
Protein	NP_062711
MGI	49119

Rattus norvegicus

mRNA	NM_031740
Protein	NP_113928

J. Biol. Chem. 1999-12-01 ;1473(1):35-53.

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

Amado M. et al. PMID:10580128

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR031569 GlyTouCan: G71142DF GlyCosmos Glycans: G71142DF	UDP-Gal	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

J. Biol. Chem. 1998-05-01 ;273(22):13570-7.

Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain.

Nomura T. et al. PMID:9593693 Refer to: Fig. 3 (A S), Fig. 8 (Northern)

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR031569 GlyTouCan: G71142DF GlyCosmos Glycans: G71142DF	UDP-Gal	JCGG-STR001961 GlyTouCan: G84224TW GlyCosmos Glycans: G84224TW

RNA Expression from Human Protein Atlas

This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Biochim. Biophys. Acta 1999-05-01 ;1438(2):301-4.

cDNA cloning and expression of human lactosylceramide synthase.

Takizawa M. et al. PMID:10320813

J. Biol. Chem. 1998-05-01 ;273(22):13570-7.

Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain.

Nomura T. et al. PMID:9593693

Glycobiology 1998-05-01 ;8(5):517-26.

The expanding beta 4-galactosyltransferase gene family: messages from the databanks.

Lo NW. et al. PMID:9597550

brainfetal brainfetal kidneyfetal liverfetal lungkidneypancreasskeletal muscle

Provided by GOA

Function
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
galactosyltransferase activity
metal ion binding

Process
keratan sulfate biosynthetic process
keratan sulfate synthesis
protein glycosylation

Component
Golgi cisterna membrane
Golgi membrane
integral component of membrane

B4GALT6

Galactosyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Identification and characterization of large galactosyltransferase gene families: galactosyltransferases for all functions.

DONOR : UDP-Gal

Substrate Transferred

Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain.

DONOR : UDP-Gal

Substrate Transferred

Acceptor Substrates (KEM-C)

Expression

Expression (Reference)

cDNA cloning and expression of human lactosylceramide synthase.

Purification, cDNA cloning, and expression of UDP-Gal: glucosylceramide beta-1,4-galactosyltransferase from rat brain.

The expanding beta 4-galactosyltransferase gene family: messages from the databanks.

Gene Ontology