CGT

Last Update:2016-01-29

Galactosyl ceramide synthase (CGT) belongs to the UDP-galactosyltransferase family and transfers galactose to ceramide, synthesizing galactosylceramides (GalC). GalC are mainly expressed in the myelin of the central and peripheral nervous systems. Lack of CGT lose GalC and GalC-derived sulfatides from myeline glycolipids, demonstrating that CGT is a sole and key enzyme in GalC synthesis. Another gene symbol approved by HGNC is UGT8.

Keyword: galactocerebroside
Cer
UDP-Gal 		Galb1-Cer

Galactosyltransferase


GGDB Symbol CGT    Alias
DesignationUDP-Galactose ceramide galactosyl transferase
OrganismHomo sapiens
GeneID 7368
HGNC UGT8 (12555)
mRNA NM_003360
map4q26
Protein NP_003351
EC# 2.4.1.45   
CAZy GT7   
GlyCosmos Glycogenes CGT
OMIM 601291
Disease name
GDGDB
Human Protein Atlas ENSG00000174607
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Orthologous Gene

Acceptor Substrates (Reference)

Acceptor Substrates (KEM-C)

Expression

RNA Expression from Human Protein Atlas
This RNA expression data uses "HPA data" from the Human Protein Atlas. Tissue RNA Expression

data available from v22.proteinatlas.org

Expression (Reference)

Gene Ontology

This page does not indicate all of the enzymatic reaction, and expression of "CGT".