GGDB:

This enzyme is the enzyme that synthesizes B antigen, which is the blood group carbohydrate antigen, encoded by the ABO gene. Its enzyme activity is a1,3-galactosyltransferase activity that transfers Gal from the donor UDP-Gal to the galactose residue of the non-reducing terminal of the acceptor (H type carbohydrate antigen) by an a1-3 bond.

Keyword: B blood type , Histo-Blood group antigen , α1,3-Galactosyltransferase

	UDP-Gal
JCGG-STR031477 GlyTouCan: G64904FE GlyCosmos Glycans: G64904FE		JCGG-STR031481 GlyTouCan: G14646AF GlyCosmos Glycans: G14646AF

	UDP-Gal
JCGG-STR021430 GlyTouCan: G00068MO GlyCosmos Glycans: G00068MO		JCGG-STR021986 GlyTouCan: G47548GA GlyCosmos Glycans: G47548GA

Galactosyltransferase

GGDB Symbol

B(ABO) Alias

Designation

alpha 1,3-galactosyltransferase

Organism

Homo sapiens

GeneID

HGNC

ABO (79)

mRNA

NM_020469

map

9q34.1-q34.2

Protein

NP_065202

EC#

2.4.1.37

CAZy

GT6

GlyCosmos Glycogenes

B(ABO)

OMIM

110300

Disease name

GDGDB

Human Protein Atlas

ENSG00000175164

Mus musculus

mRNA	NM_030718
Protein	NP_109643

Rattus norvegicus

mRNA	NM_023094
Protein	NP_075582

Semin. Hematol. 1990-01-01 ;265(2):1139-45.

Isolation to homogeneity and partial characterization of a histo-blood group A defined Fuc alpha 1----2Gal alpha 1----3-N-acetylgalactosaminyltransferase from human lung tissue.

Clausen H. et al. PMID:2104827

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR021430 GlyTouCan: G00068MO GlyCosmos Glycans: G00068MO	UDP-Gal	JCGG-STR021986 GlyTouCan: G47548GA GlyCosmos Glycans: G47548GA

Semin. Hematol. 1990-11-01 ;265(31):19257-62.

Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid substitutions.

Yamamoto F. et al. PMID:2121736

Nature 1990-05-01 ;345(6272):229-33.

Molecular genetic basis of the histo-blood group ABO system.

Yamamoto F. et al. PMID:2333095

Semin. Hematol. 1986-01-01 ;51(3):161-71.

Genetics of ABO, H, Lewis, X and related antigens.

Oriol R. et al. PMID:2433836

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR033516 GlyTouCan: G17425GC GlyCosmos Glycans: G17425GC	UDP-Gal	JCGG-STR033530 GlyTouCan: G53449FY GlyCosmos Glycans: G53449FY

	JCGG-STR033518 GlyTouCan: G78693BX GlyCosmos Glycans: G78693BX	UDP-Gal	JCGG-STR033531 GlyTouCan: G08589UI GlyCosmos Glycans: G08589UI

	JCGG-STR033520 GlyTouCan: G62735WZ GlyCosmos Glycans: G62735WZ	UDP-Gal	JCGG-STR033532 GlyTouCan: G29100FF GlyCosmos Glycans: G29100FF

	JCGG-STR033533 GlyTouCan: G16673GG GlyCosmos Glycans: G16673GG	UDP-Gal	JCGG-STR029766 GlyTouCan: G19620VP GlyCosmos Glycans: G19620VP

Nature 1989-01-01 ;56(1):1-20.

ABH and related histo-blood group antigens; immunochemical differences in carrier isotypes and their distribution.

Clausen H. et al. PMID:2464874

Nature 1981-01-01 ;18(1):39-62.

Blood group ABH and Ii antigens of human erythrocytes: chemistry, polymorphism, and their developmental change.

Hakomori S. et al. PMID:6782678

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

	JCGG-STR033516 GlyTouCan: G17425GC GlyCosmos Glycans: G17425GC	UDP-Gal	JCGG-STR033530 GlyTouCan: G53449FY GlyCosmos Glycans: G53449FY

	JCGG-STR033518 GlyTouCan: G78693BX GlyCosmos Glycans: G78693BX	UDP-Gal	JCGG-STR033531 GlyTouCan: G08589UI GlyCosmos Glycans: G08589UI

	JCGG-STR033520 GlyTouCan: G62735WZ GlyCosmos Glycans: G62735WZ	UDP-Gal	JCGG-STR033532 GlyTouCan: G29100FF GlyCosmos Glycans: G29100FF

	JCGG-STR033533 GlyTouCan: G16673GG GlyCosmos Glycans: G16673GG	UDP-Gal	JCGG-STR029766 GlyTouCan: G19620VP GlyCosmos Glycans: G19620VP

DONOR : UDP-Gal

Glc	Man	Gal	GlcNAc	GalNAc	Fuc	Xyl	Neu5Ac	Neu5Gc	GlcA	IdoA	GlcN

Substrate Transferred

		UDP-Gal
	JCGG-STR031452 GlyTouCan: G14380OJ GlyCosmos Glycans: G14380OJ		JCGG-STR031454 GlyTouCan: G43946PN GlyCosmos Glycans: G43946PN

		UDP-Gal
	JCGG-STR004807 GlyTouCan: G38351JR GlyCosmos Glycans: G38351JR		JCGG-STR031457 GlyTouCan: G28599FB GlyCosmos Glycans: G28599FB

		UDP-Gal
	JCGG-STR031458 GlyTouCan: G76763LN GlyCosmos Glycans: G76763LN		JCGG-STR031460 GlyTouCan: G00924FH GlyCosmos Glycans: G00924FH

		UDP-Gal
	JCGG-STR003781 GlyTouCan: G94514IB GlyCosmos Glycans: G94514IB		JCGG-STR031485 GlyTouCan: G10706IL GlyCosmos Glycans: G10706IL

		UDP-Gal
	JCGG-STR031490 GlyTouCan: G53542OI GlyCosmos Glycans: G53542OI		JCGG-STR031492 GlyTouCan: G25044JE GlyCosmos Glycans: G25044JE

		UDP-Gal
	JCGG-STR031487 GlyTouCan: G45304XA GlyCosmos Glycans: G45304XA		JCGG-STR031489 GlyTouCan: G54335XN GlyCosmos Glycans: G54335XN

		UDP-Gal
	JCGG-STR021049 GlyTouCan: G94435QH GlyCosmos Glycans: G94435QH		JCGG-STR030667 GlyTouCan: G88313DY GlyCosmos Glycans: G88313DY

		UDP-Gal
	JCGG-STR028041 GlyTouCan: G47180UC GlyCosmos Glycans: G47180UC		JCGG-STR031475 GlyTouCan: G73314OH GlyCosmos Glycans: G73314OH

		UDP-Gal
	JCGG-STR031477 GlyTouCan: G64904FE GlyCosmos Glycans: G64904FE		JCGG-STR031481 GlyTouCan: G14646AF GlyCosmos Glycans: G14646AF

Substrate Not Transferred


	JCGG-STR004625 GlyTouCan: G11647UD GlyCosmos Glycans: G11647UD


	JCGG-STR004557 GlyTouCan: G19749DC GlyCosmos Glycans: G19749DC


	JCGG-STR027300 GlyTouCan: G32723SL GlyCosmos Glycans: G32723SL

B(ABO)

Galactosyltransferase

Orthologous Gene

Mus musculus

Rattus norvegicus

Acceptor Substrates (Reference)

Isolation to homogeneity and partial characterization of a histo-blood group A defined Fuc alpha 1----2Gal alpha 1----3-N-acetylgalactosaminyltransferase from human lung tissue.

DONOR : UDP-Gal

Substrate Transferred

Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid substitutions.

Molecular genetic basis of the histo-blood group ABO system.

Genetics of ABO, H, Lewis, X and related antigens.

DONOR : UDP-Gal

Substrate Transferred

ABH and related histo-blood group antigens; immunochemical differences in carrier isotypes and their distribution.

Blood group ABH and Ii antigens of human erythrocytes: chemistry, polymorphism, and their developmental change.

DONOR : UDP-Gal

Substrate Transferred

Acceptor Substrates (KEM-C)

DONOR : UDP-Gal

Substrate Transferred

Substrate Not Transferred

Expression

Expression (Reference)

Gene Ontology